Cytotoxic tirucallaneC26 triterpenoids from the stem barks of Aphanamixis grandifolia

被引：43

作者：

Zhang, Yao ^{[1
]}

Wang, Junsong ^{[1
]}

Wei, Dandan ^{[1
]}

Wang, Xiaobing ^{[1
]}

Luo, Jun ^{[1
]}

Luo, Jianguang ^{[1
]}

Kong, Lingyi ^{[1
]}

机构：

[1] China Pharmaceut Univ, Dept Nat Med Chem, Nanjing 210009, Peoples R China

来源：

PHYTOCHEMISTRY | 2010年 / 71卷 / 17-18期

基金：

中国国家自然科学基金;

关键词：

Aphanamixis grandifolia; Tirucallane; Meliaceae; Triterpenoids; Cytotoxicity; FUNGUS FOMITOPSIS-PINICOLA; AMOORA-DASYCLADA; GANODERMA-TSUGAE; STEROIDS; CONSTITUENTS; FRUITS;

D O I：

10.1016/j.phytochem.2010.08.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Five tirucallane type C-26 triterpenoids accompanied by two known compounds 3 alpha-hydroxy-24 25 26 27-tetranortirucall-7-ene-23(21)-lactone and 3-oxo-24 25 26 27-tetranortirucall-7-ene-23(21)-lactone were isolated from the stem barks of Aphanamixis grandifolia Their structures were established mainly by means of a combination of 1D and 2D NMR spectroscopic and mass spectrometry techniques as 3 alpha-hydroxyl-21 alpha-methoxy-24 25 26 27-tetranortirucall-7-ene-23(21)-lactone 3 alpha-hydroxy-21 beta-methoxy-24 25 26 27-tetranortirucall-7-ene-23(21)-lactone 3-oxo-21 alpha-methoxy-24 25 26 27-tetranortirucall-7-ene-23(21)-lactone 3-oxo-21 beta-methoxy-24 25 26 27-tetranortirucall-7-ene-23 (21)-lactone and 3-oxo-21 alpha-ethoxy-24 25 26 27-tetranortirucall-7-ene-23(21)-lactone All Isolates were in vitro evaluated for their cytotoxic activities against five tumor cell lines (MCF-7 HeLa HepG2 SGC-7901 and BGC-823) (C) 2010 Elsevier Ltd All rights reserved

引用

页码：2199 / 2204

页数：6

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