The impact of microgravity on bone in humans

被引：201

作者：

Grimm, Daniela ^{[1
]}

Grosse, Jirka ^{[2
]}

Wehland, Markus ^{[3
]}

Mann, Vivek ^{[4
]}

Reseland, Janne Elin ^{[5
]}

Sundaresan, Alamelu ^{[4
]}

Corydon, Thomas Juhl ^{[1
]}

机构：

[1] Aarhus Univ, Dept Biomed, Wilhelm Meyers Alle 4, DK-8000 Aarhus C, Denmark

[2] Univ Regensburg, Dept Nucl Med Germany, D-93042 Regensburg, Germany

[3] Otto Von Guericke Univ, Clin Plast Aesthet & Hand Surg, D-39120 Magdeburg, Germany

[4] Texas So Univ, Dept Biol, 3100 Cleburne, Houston, TX 77004 USA

[5] Univ Oslo, Fac Dent, Dept Biomat, N-0317 Oslo, Norway

来源：

BONE | 2016年 / 87卷

关键词：

Microgravity; Metabolism; Calcium; Bone loss; Countermeasures; RENAL STONE RISK; THYROID-CANCER CELLS; DIFFERENTIAL GENE-EXPRESSION; RESISTIVE VIBRATION EXERCISE; BODY NEGATIVE-PRESSURE; DURATION SPACE-FLIGHT; BED-REST; SIMULATED MICROGRAVITY; RESISTANCE EXERCISE; CALCIUM-METABOLISM;

D O I：

10.1016/j.bone.2015.12.057

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Experiencing real weightlessness in space is a dream for many of us who are interested in space research. Although space traveling fascinates us, it can cause both short-term and long-term health problems. Microgravity is the most important influence on the human organism in space. The human body undergoes dramatic changes during a long-term spaceflight. In this review, we will mainly focus on changes in calcium, sodium and bone metabolism of space travelers. Moreover, we report on the current knowledge on the mechanisms of bone loss in space, available models to simulate the effects of microgravity on bone on Earth as well as the combined effects of microgravity and cosmic radiation on bone. The available countermeasures applied in space will also be evaluated. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：44 / 56

页数：13

共 185 条

[1] Moderate alterations of the cytoskeleton in human chondrocytes after short-term microgravity produced by parabolic flight maneuvers could be prevented by up-regulation of BMP-2 and SOX-9 [J].

Aleshcheva, Ganna ;

Wehland, Markus ;

Sahana, Jayashree ;

Bauer, Johann ;

Corydon, Thomas J. ;

Hemmersbach, Ruth ;

Frett, Timo ;

Egli, Marcel ;

Infanger, Manfred ;

Grosse, Jirka ;

Grimm, Daniela .

FASEB JOURNAL, 2015, 29 (06) :2303-2314

[2] Heavy ion irradiation and unloading effects on mouse lumbar vertebral microarchitecture, mechanical properties and tissue stresses [J].

Alwood, J. S. ;

Yumoto, K. ;

Mojarrab, R. ;

Limoli, C. L. ;

Almeida, E. A. C. ;

Searby, N. D. ;

Globus, R. K. .

BONE, 2010, 47 (02) :248-255

[3]

[Anonymous], BONE LOSS SPACEFLIGH

[4]

[Anonymous], GRAVIT SPACE BIOL

[5]

[Anonymous], MICROGRAVITY SCI TEC

[6]

[Anonymous], EUR J APPL PHYSL

[7]

[Anonymous], NASA

[8]

[Anonymous], J APPL PHYSL

[9]

[Anonymous], OSTEOPOROS INT

[10]

[Anonymous], BIOMEDICAL RESULTS S

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