Stress will kill you anyway!

被引：1

作者：

Belavgeni, Alexia ^{[1
]}

Bornstein, Stefan R. ^{[2
]}

Linkermann, Andreas ^{[1
,3
]}

机构：

[1] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Div Nephrol, D-01307 Dresden, Germany

[2] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dept Internal Med 3, D-01307 Dresden, Germany

[3] Tech Univ Dresden, Ctr Biotechnol, D-01307 Dresden, Germany

来源：

CELL DEATH & DISEASE | 2020年 / 11卷 / 04期

关键词：

D O I：

10.1038/s41419-020-2433-0

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Adrenocortical carcinomas are devastating cancers, expressing high levels of glutathione peroxidase 4 (GPX4). Therefore, it was recently suggested that these tumors might be therapeutically targeted by inducing ferroptosis. In this issue of Cell Death and Disease, Weigand et al. describe the organ-specific production of steroid hormones as a potential culprit for the exquisite sensitivity of these cancers to ferroptosis.

引用

页数：3

共 8 条

[1] Exquisite sensitivity of adrenocortical carcinomas to induction of ferroptosis
Belavgeni, Alexia
Bornstein, Stefan R.
von Maessenhausen, Anne
Tonnus, Wulf
Stumpf, Julian
Meyer, Claudia
Othmar, Evelyn
Latk, Markus
Kanczkowski, Waldemar
Kroiss, Matthias
Hantel, Constanze
Hugo, Christian
Fassnacht, Martin
Ziegler, Christian G.
Schally, Andrew V.
Krone, Nils P.
Linkermann, Andreas
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (44) : 22269 - 22274
[2] The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis
Bersuker, Kirill
Hendricks, Joseph M.
Li, Zhipeng
Magtanong, Leslie
Ford, Breanna
Tang, Peter H.
Roberts, Melissa A.
Tong, Bingqi
Maimone, Thomas J.
Zoncu, Roberto
Bassik, Michael C.
Nomura, Daniel K.
Dixon, Scott J.
Olzmann, James A.
[J]. NATURE, 2019, 575 (7784) : 688 - +
[3] FSP1 is a glutathione-independent ferroptosis suppressor
Doll, Sebastian
Freitas, Florencio Porto
Shah, Ron
Aldrovandi, Maceler
da Silva, Milene Costa
Ingold, Irina
Grocin, Andrea Goya
da Silva, Thamara Nishida Xavier
Panzilius, Elena
Scheel, Christina H.
Mourao, Andre
Buday, Katalin
Sato, Mami
Wanninger, Jonas
Vignane, Thibaut
Mohana, Vaishnavi
Rehberg, Markus
Flatley, Andrew
Schepers, Aloys
Kurz, Andreas
White, Daniel
Sauer, Markus
Sattler, Michael
Tate, Edward William
Schmitz, Werner
Schulze, Almut
O'Donnell, Valerie
Proneth, Bettina
Popowicz, Grzegorz M.
Pratt, Derek A.
Angeli, Jose Pedro Friedmann
Conrad, Marcus
[J]. NATURE, 2019, 575 (7784) : 693 - +
[4] Ferroptotic cell death and TLR4/Trif signaling initiate neutrophil recruitment after heart transplantation
Li, Wenjun
Feng, Guoshuai
Gauthier, Jason M.
Lokshina, Inessa
Higashikubo, Ryuji
Evans, Sarah
Liu, Xinping
Hassan, Adil
Tanaka, Satona
Cicka, Markus
Hsiao, Hsi-Min
Ruiz-Perez, Daniel
Bredemeyer, Andrea
Gross, Richard W.
Mann, Douglas L.
Tyurina, Yulia Y.
Gelman, Andrew E.
Kagan, Valerian E.
Linkermann, Andreas
Lavine, Kory J.
Kreisel, Daniel
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2019, 129 (06) : 2293 - 2304
[5] ORIGIN AND CONSEQUENCES OF NECROINFLAMMATION
Sarhan, Maysa
Land, Walter G.
Tonnus, Wulf
Hugo, Christian P.
Linkermann, Andreas
[J]. PHYSIOLOGICAL REVIEWS, 2018, 98 (02) : 727 - 780
[6] The pathological features of regulated necrosis
Tonnus, Wulf
Meyer, Claudia
Paliege, Alexander
Belavgeni, Alexia
von Maessenhausen, Anne
Bornstein, Stefan R.
Hugo, Christian
Becker, Jan Ulrich
Linkermann, Andreas
[J]. JOURNAL OF PATHOLOGY, 2019, 247 (05) : 697 - 707
[7] Active steroid hormone synthesis renders adrenocortical cells highly susceptible to type II ferroptosis induction
Weigand, Isabel
Schreiner, Jochen
Roehrig, Florian
Sun, Na
Landwehr, Laura-Sophie
Urlaub, Hanna
Kendl, Sabine
Kiseljak-Vassiliades, Katja
Wierman, Margaret E.
Angeli, Jose Pedro Friedmann
Walch, Axel
Sbiera, Silviu
Fassnacht, Martin
Kroiss, Matthias
[J]. CELL DEATH & DISEASE, 2020, 11 (03)
[8] Regulation of Ferroptotic Cancer Cell Death by GPX4
Yang, Wan Seok
SriRamaratnam, Rohitha
Welsch, Matthew E.
Shimada, Kenichi
Skouta, Rachid
Viswanathan, Vasanthi S.
Cheah, Jaime H.
Clemons, Paul A.
Shamji, Alykhan F.
Clish, Clary B.
Brown, Lewis M.
Girotti, Albert W.
Cornish, Virginia W.
Schreiber, Stuart L.
Stockwell, Brent R.
[J]. CELL, 2014, 156 (1-2) : 317 - 331

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