Antiproliferative effects of several compounds isolated from Amburana cearensis A. C.!Smith

被引：0
|
作者：
Costa-Lotufo, LV
Jimenez, PC
Wilke, DV
Leal, LKAM
Cunha, GMA
Silveira, ER
Cannto, KM
Viana, GSB
Moraes, MEA
de Moraes, MO
Pessoa, C
机构：
[1] Fed Univ Ceara, Fac Med, Dept Physiol & Pharmacol, BR-60430270 Fortaleza, Ceara, Brazil
[2] Fed Univ Ceara, Dept Organ & Inorgan Chem, BR-60021940 Fortaleza, Ceara, Brazil
来源：
ZEITSCHRIFT FUR NATURFORSCHUNG C-A JOURNAL OF BIOSCIENCES | 2003年 / 58卷 / 9-10期
关键词：
Amburana cearensis; kaempferol; isokaempferide;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Amburana cearensis a common tree found in Northeastern Brazil is widely used in folk medicine. The present work evaluated the cytotoxicity of kaempferol, isokaempferide, amburoside A and protocatechuic acid isolated from the ethanol extract of the trunk bark of A. cearensis. The compounds were tested for their cytotoxicity on the sea urchin egg development, hemolysis assay and 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide assay using tumor cell lines. Isokaempferide and kaempferol, but not amburoside A and protocatechuic acid, inhibited the sea urchin egg development as well as tumor cell lines, but in this assay isokaempferide was more potent than kaempferol. Protocatechuic acid was the only compound able to induce hemolysis of mouse erythrocytes, suggesting that the cytotoxicity of kaempferol and isokaempeferide was not related to membrane damage.
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收藏
页码：675 / 680
页数：6
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