Neonatal clomipramine induced endogenous depression in rats is associated with learning impairment in adulthood

被引：35

作者：

Bhagya, V. ^{[1
]}

Srikumar, B. N. ^{[1
]}

Raju, T. R. ^{[1
]}

Rao, B. S. Shankaranarayana ^{[1
]}

机构：

[1] Natl Inst Mental Hlth & Neurosci, Dept Neurophysiol, Bangalore 560029, Karnataka, India

来源：

BEHAVIOURAL BRAIN RESEARCH | 2008年 / 187卷 / 01期

关键词：

radial arm maze; spatial memory; forced swim test; sucrose consumption test; serotonin; hippocampus;

D O I：

10.1016/j.bbr.2007.08.020

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Clinical studies show cognitive impairment in depression. However, the neural substrates underlying these remain elusive. Hence, we have examined the effect of neonatal clomipramine treatment on cognition in adulthood. The neonatal clomipramine treated rats displayed a profound impairment in partially baited 8-arm radial maze task. This work provides a novel perspective into neural basis of depression associated cognitive changes and help in development of therapeutic strategies to treat depression related memory dysfunctions. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：190 / 194

页数：5

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