Plasma levels of vascular endothelial growth factor and fibroblast growth factor 2 in patients with major depressive disorders

被引：75

作者：

Takebayashi, M. ^{[1
,2
]}

Hashimoto, R. ^{[3
,4
,5
,6
,7
,8
]}

Hisaoka, K. ^{[2
]}

Tsuchioka, M. ^{[2
]}

Kunugi, H. ^{[3
,8
]}

机构：

[1] Natl Hosp Org, Kure Med Ctr, Dept Psychiat, Kure 7370023, Japan

[2] Natl Hosp Org, Kure Med Ctr, Div Psychiat & Neurosci, Inst Clin Res, Kure 7370023, Japan

[3] Natl Ctr Neurol & Psychiat, Dept Mental Disorder Res, Natl Inst Neurosci, Tokyo, Japan

[4] Osaka Univ, Mol Res Ctr Childrens Mental Dev, United Grad Sch Child Dev, Osaka, Japan

[5] Kanazawa Univ, Sch Med, Kanazawa, Ishikawa 920, Japan

[6] Hamamatsu Univ Sch Med, Hamamatsu, Shizuoka 4312102, Japan

[7] Osaka Univ, Grad Sch Med, Dept Psychiat, Osaka, Japan

[8] JST, CREST, Tokyo, Japan

来源：

JOURNAL OF NEURAL TRANSMISSION | 2010年 / 117卷 / 09期

基金：

日本学术振兴会;

关键词：

VEGF; FGF-2; Plasma; Family history; Mood disorders; INCREASE; BDNF;

D O I：

10.1007/s00702-010-0452-1

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We investigated the plasma levels of VEGF and FGF-2, important factors for regulation of neuroplasticity such as neurogenesis, in patients in remission from major depressive disorders (MDD). The plasma VEGF levels were significantly higher in the MDD patients than in the matched control subjects, while no significant difference in plasma FGF-2 levels was found. In particular, the MDD patients with family history of psychiatric disorders, but not patients without such a family history, showed significantly higher values of plasma VEGF than the controls. Although this is a preliminary study, altered VEGF levels might be involved in the pathophysiology of MDD.

引用

收藏

页码：1119 / 1122

页数：4

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