Now, swing your partner! 3D-domain switching of WASP activates Arp2/3 complex

被引：3
作者：
Hitchcock-DeGregori, SE [1 ]
机构：
[1] Robert Wood Johnson Med Sch, Dept Neurosci & Cell Biol, Piscataway, NJ 08854 USA
来源：
NATURE STRUCTURAL BIOLOGY | 2003年 / 10卷 / 08期
关键词：
WASP/SCAR PROTEINS; DOMAINS; ACTIN;
D O I：
10.1038/nsb0803-583
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Structural and functional analysis of WASP family cell signaling proteins shows that the same residues that are sequestered upon GTPase binding in the autoinhibited state are involved in binding to and activating Arp2/3 complex, WASP's downstream partner in the signaling cascade.
引用
收藏
页码：583 / 584
页数：2
相关论文
共 12 条
[1]   ERM-merlin and EBP50 protein families in plasma membrane organization and function [J].
Bretscher, A ;
Chambers, D ;
Nguyen, R ;
Reczek, D .
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2000, 16 :113-+
[2]   Regulation of Wiskott-Aldrich syndrome protein and related molecules [J].
Caron, E .
CURRENT OPINION IN CELL BIOLOGY, 2002, 14 (01) :82-87
[3]   The taming of the SNARE [J].
Carr, CM .
NATURE STRUCTURAL BIOLOGY, 2001, 8 (03) :186-188
[4]   Constitutively activating mutation in WASP causes X-linked severe congenital neutropenia [J].
Devriendt, K ;
Kim, AS ;
Mathijs, G ;
Frints, SGM ;
Schwartz, M ;
Van den Oord, JJ ;
Verhoef, GEG ;
Boogaerts, MA ;
Fryns, JP ;
You, DQ ;
Rosen, MK ;
Vandenberghe, P .
NATURE GENETICS, 2001, 27 (03) :313-317
[5]   Rho GTPases in cell biology [J].
Etienne-Manneville, S ;
Hall, A .
NATURE, 2002, 420 (6916) :629-635
[6]   Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein [J].
Kim, AS ;
Kakalis, LT ;
Abdul-Manan, M ;
Liu, GA ;
Rosen, MK .
NATURE, 2000, 404 (6774) :151-158
[7]   3D domain swapping: As domains continue to swap [J].
Liu, Y ;
Eisenberg, D .
PROTEIN SCIENCE, 2002, 11 (06) :1285-1299
[8]   Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex [J].
Marchand, JB ;
Kaiser, DA ;
Pollard, TD ;
Higgs, HN .
NATURE CELL BIOLOGY, 2001, 3 (01) :76-82
[9]   The Wiskott-Aldrich syndrome [J].
Ochs, HD .
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY, 2001, 20 (01) :61-86
[10]   A conserved amphipathic helix in WASP/Scar proteins is essential for activation of Arp2/3 complex [J].
Panchal, SC ;
Kaiser, DA ;
Torres, E ;
Pollard, TD ;
Rosen, MK .
NATURE STRUCTURAL BIOLOGY, 2003, 10 (08) :591-598
12