Changes in albuminuria and renal outcome in patients with type 2 diabetes and hypertension: a real-life observational study

被引:9
作者
Viazzi, Francesca [1 ]
Ceriello, Antonio [2 ,3 ,4 ]
Fioretto, Paola [5 ]
Giorda, Carlo [6 ]
Guida, Pietro [7 ,8 ]
Russo, Giuseppina [9 ]
Greco, Eulalia [10 ]
De Cosmo, Salvatore [9 ]
Pontremoli, Roberto [1 ]
机构
[1] Univ Genoa, IRCCS Azienda Osped Univ San Martino IST, Genoa, Italy
[2] Inst Invest Biomed August Pii Sunyer IDIBAPS, Barcelona, Spain
[3] Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid, Spain
[4] IRCCS Grp Multimed, Dept Cardiovasc & Metab Dis, Milan, Italy
[5] Univ Padua, Dept Med, Padua, Italy
[6] ASL Turin 5, Diabet & Metab Unit, Turin, Italy
[7] Associaz Med Diabetol, Rome, Italy
[8] IRCCS Inst Cassano Murge, Sci Clin Inst Maugeri, Bari, Italy
[9] Univ Messina, Dept Clin & Expt Med, Messina, Italy
[10] IRCCS Casa Sollievo Sofferenza, Dept Med Sci, Foggia, Italy
关键词
albuminuria; glomerular filtration rate; hypertension; type; 2; diabetes; APPROPRIATE THERAPEUTIC TARGET; SURROGATE END-POINT; CARDIOVASCULAR EVENTS; SUBSEQUENT RISK; KIDNEY-DISEASE; PROTEINURIA; PROGRESSION; NEPHROPATHY; REGRESSION; CKD;
D O I
10.1097/HJH.0000000000001749
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Objectives: To assess the predictive role of changes in albuminuria on the loss of renal function under antihypertensive treatment in patients with type 2 diabetes (T2D). Methods: Clinical records from a total of 12 611 patients with hypertension and T2D, attending 100 antidiabetic centers in Italy, with normal estimated glomerular filtration rate (eGFR) at baseline and regular visits during a 4-year period were retrieved and analyzed. We assessed the association between changes in albuminuria status during a 1-year baseline period and time updated blood pressure (BP) and eGFR loss over the subsequent 4-year follow-up. Results: Mean age at baseline was 65 +/- 9 years, known duration of diabetes11 +/- 8 years, eGFR 85 +/- 13 ml/min and BP 142 +/- 17/81 +/- 9 mmHg. Patients with persistent albuminuria showed the highest 4-year risk of eGFR loss more than 30% from baseline or onset of stage 3 chronic kidney disease (eGFR <60 ml/min) as compared with those with persistent normal albuminuria (odds ratio 2.00, confidence interval 1.71-234; P <0.001). Female sex, age, disease duration, BMI, low baseline eGFR, lipid profile, the number of antihypertensive drugs and variations in albuminuria status were associated with renal risk in the whole study population. Furthermore, lower time updated BP values and the use of renin-angiotensin-aldosterone-system-inhibitors were related to the occurrence of renal endpoints only in the subgroup of patients without albuminuria. Conclusion: In patients with hypertension and T2D under real-life clinical conditions, changes in albuminuria parallel changes of renal risk. Albuminuria status could be a guide to optimize therapeutic strategy.
引用
收藏
页码:1719 / 1728
页数:10
相关论文
共 32 条
[1]   Racial/Ethnic Differences in the Prevalence of Proteinuric and Nonproteinuric Diabetic Kidney Disease [J].
Bhalla, Vivek ;
Zhao, Beinan ;
Azar, Kristen M. J. ;
Wang, Elsie J. ;
Choi, Sarah ;
Wong, Eric C. ;
Fortmann, Stephen P. ;
Palaniappan, Latha P. .
DIABETES CARE, 2013, 36 (05) :1215-1221
[2]   The role of proteinuria in the progression of chronic renal failure [J].
Burton, C ;
Harris, KPG .
AMERICAN JOURNAL OF KIDNEY DISEASES, 1996, 27 (06) :765-775
[3]   Albuminuria changes are associated with subsequent risk of end-stage renal disease and mortality [J].
Carrero, Juan Jesus ;
Grams, Morgan E. ;
Sang, Yingying ;
Arnlov, Johan ;
Gasparini, Alessandro ;
Matsushita, Kunihiro ;
Qureshi, Abdul R. ;
Evans, Marie ;
Barany, Peter ;
Lindholm, Bengt ;
Ballew, Shoshana H. ;
Levey, Andrew S. ;
Gansevoort, Ron T. ;
Elinder, Carl G. ;
Coresh, Josef .
KIDNEY INTERNATIONAL, 2017, 91 (01) :244-251
[4]   Decline in Estimated Glomerular Filtration Rate and Subsequent Risk of End-Stage Renal Disease and Mortality [J].
Coresh, Josef ;
Turin, Tanvir Chowdhury ;
Matsushita, Kunihiro ;
Sang, Yingying ;
Ballew, Shoshana H. ;
Appel, Lawrence J. ;
Arima, Hisatomi ;
Chadban, Steven J. ;
Cirillo, Massimo ;
Djurdjev, Ognjenka ;
Green, Jamie A. ;
Heine, Gunnar H. ;
Inker, Lesley A. ;
Irie, Fujiko ;
Ishani, Areef ;
Ix, Joachim H. ;
Kovesdy, Csaba P. ;
Marks, Angharad ;
Ohkubo, Takayoshi ;
Shalev, Varda ;
Shankar, Anoop ;
Wen, Chi Pang ;
de Jong, Paul E. ;
Iseki, Kunitoshi ;
Stengel, Benedicte ;
Gansevoort, Ron T. ;
Levey, Andrew S. .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2014, 311 (24) :2518-2531
[5]   Proteinuria should be used as a surrogate in CKD [J].
Cravedi, Paolo ;
Ruggenenti, Piero ;
Remuzzi, Giuseppe .
NATURE REVIEWS NEPHROLOGY, 2012, 8 (05) :301-306
[6]   Albuminuria Changes and Cardiovascular and Renal Outcomes in Type 1 Diabetes: The DCCT/EDIC Study [J].
de Boer, Ian H. ;
Gao, Xiaoyu ;
Cleary, Patricia A. ;
Bebu, Ionut ;
Lachin, John M. ;
Molitch, Mark E. ;
Orchard, Trevor ;
Paterson, Andrew D. ;
Perkins, Bruce A. ;
Steffes, Michael W. ;
Zinman, Bernard .
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2016, 11 (11) :1969-1977
[7]   Serum Uric Acid and Risk of CKD in Type 2 Diabetes [J].
De Cosmo, Salvatore ;
Viazzi, Francesca ;
Pacilli, Antonio ;
Giorda, Carlo ;
Ceriello, Antonio ;
Gentile, Sandro ;
Russo, Giuseppina ;
Rossi, Maria C. ;
Nicolucci, Antonio ;
Guida, Pietro ;
Feig, Daniel ;
Johnson, Richard J. ;
Pontremoli, Roberto .
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2015, 10 (11) :1921-1929
[8]   Proteinuria, a target for renoprotection in patients with type 2 diabetic nephropathy: Lessons from RENAAL [J].
de Zeeuw, D ;
Remuzzi, G ;
Parving, HH ;
Keane, WF ;
Zhang, ZX ;
Shahinfar, S ;
Snapinn, S ;
Cooper, MF ;
Mitch, WE ;
Brenner, BM .
KIDNEY INTERNATIONAL, 2004, 65 (06) :2309-2320
[9]   Albuminuria is Not an Appropriate Therapeutic Target in Patients with CKD: The Con View [J].
Fried, Linda F. ;
Lewis, Julia .
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2015, 10 (06) :1089-1093
[10]   CLINICAL DIABETIC NEPHROPATHY - NATURAL-HISTORY AND COMPLICATIONS [J].
GRENFELL, A ;
WATKINS, PJ .
CLINICS IN ENDOCRINOLOGY AND METABOLISM, 1986, 15 (04) :783-805