Endoscopic submucosal dissection with a combination of small-caliber-tip transparent hood and flex knife for superficial esophageal neoplasia. Is it safe for elderly patients?

被引：17

作者：

Ishii, Naoki ^{[1
]}

Uchida, Shino ^{[1
]}

Itoh, Toshiyuki ^{[1
,2
]}

Horiki, Noriyuki ^{[1
]}

Matsuda, Michitaka ^{[1
]}

Setoyama, Takeshi ^{[1
]}

Suzuki, Shoko ^{[1
]}

Uemura, Masayo ^{[1
]}

Iizuka, Yusuke ^{[1
]}

Fukuda, Katsuyuki ^{[1
]}

Suzuki, Koyu ^{[3
]}

Fujita, Yoshiyuki ^{[1
]}

机构：

[1] St Lukes Int Hosp, Dept Gastroenterol, Chuo Ku, Tokyo 1048560, Japan

[2] Kyoto Univ Hosp, Integrated Clin Educ Ctr, Tokyo, Japan

[3] St Lukes Int Hosp, Dept Pathol, Tokyo 1048560, Japan

来源：

SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES | 2010年 / 24卷 / 09期

关键词：

Endoscopic submucosal dissection; Endoscopic mucosal resection; Esophageal neoplasia; Esophageal cancer; Elderly patient; SQUAMOUS-CELL CARCINOMA; EARLY GASTRIC-CANCER; EN-BLOC RESECTION; MUCOSAL RESECTION; SODIUM HYALURONATE; EARLY ADENOCARCINOMA; LOCAL RECURRENCE; IMMUNE-SYSTEM; TUMORS; CLASSIFICATION;

D O I：

10.1007/s00464-010-0907-3

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Background Safety and efficacy of endoscopic submucosal dissection (ESD) for esophageal neoplasias have not been adequately investigated in elderly patients. This study was designed to evaluate the safety and efficacy of ESD for esophageal neoplasias in elderly patients. Methods Fifty-three superficial esophageal neoplasias treated with ESD using a combination of small-caliber-tip transparent hood and flex knife from May 2006 to June 2009 were divided into elderly group (aged 70 years or older: 25 lesions in 23 patients) and nonelderly group (younger than aged 70 years: 28 lesions in 25 patients). Therapeutic efficacy, complications, and follow-up results were evaluated retrospectively. Results The history of cerebral infarction or cardiopulmonary disease and the usage of antiplatelet agents or anticoagulants were significantly higher in elderly group (p 0.0050 and p 0.0013, respectively). Median procedural times in the elderly group and the nonelderly group were 93 +/- 53 (range, 42-235) min and 95 +/- 55 (range, 40-230) min (p 0.73), respectively. Median sizes of the neoplasias and the resected specimens were 14 +/- 11 (range, 5-45) mm and 15 +/- 17 (range, 5-83) mm (p 0.56), and 35 +/- 12 (range, 18-60) mm and 38 +/- 17 (range, 18-90) mm (p 0.38), respectively. En bloc resection rate was 100% in each group. Body temperature and white blood cell counts of the next day after ESD were significantly higher in the nonelderly group than in the elderly group (p 0.0087 and p 0.0043, respectively). There were no complications, such as postoperative bleeding or perforation, in each group. The median follow-up period of 23 +/- 10 (range, 4-35) months in the elderly group revealed no local or distant metastasis. Conclusions ESD with a combination of small-caliber-tip transparent hood and flex knife is a safe and effective treatment for superficial esophageal neoplasia in elderly and nonelderly patients.

引用

页码：2110 / 2119

页数：10

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