L-Arginine in coronary atherosclerosis

被引：25
作者：
Tentolouris, C
Tousoulis, D
Goumas, G
Stefanadis, C
Davies, G
Toutouzas, P
机构：
[1] Univ Athens, Sch Med, Hippokrat Hosp, Cardiol Unit, GR-11527 Athens, Greece
[2] Imperial Coll, Sch Med, Hammersmith Hosp, Cardiol Unit, London, England
来源：
INTERNATIONAL JOURNAL OF CARDIOLOGY | 2000年 / 75卷 / 2-3期
关键词：
endothelium; nitric oxide; atherosclerosis; L-arginine;
D O I：
10.1016/S0167-5273(00)00320-X
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Nitric oxide is formed from the N-guanido terminal of the amino acid L-arginine and from molecular oxygen by nitric oxide synthase enzymes. L-arginine administration improves the coronary blood flow response to acetylcholine in patients with normal coronary arteries and hypercholesterolemia, reverses the defective endothelium-dependent vasodilation associated with an elevated plasma low-density lipoprotein level or hypercholesterolemia, dilates coronary epicardial arteries and stenoses, enhances nitric oxide generation, and inhibits lesion formation after balloon angioplasty. Stimulation of endogenous nitric oxide production could inhibit atherogenesis, and therefore may be of benefit in patients with risk factors for atherosclerosis. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：123 / 128
页数：6
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