The gut-kidney axis in chronic renal failure: A new potential target for therapy

被引：64
作者：
Khoury, Tawfik [1 ,2 ]
Tzukert, Keren [3 ]
Abel, Roy [3 ]
Abu Rmeileh, Ayman [1 ,2 ]
Levi, Ronen [3 ]
Ilan, Yaron [1 ,2 ]
机构：
[1] Hebrew Univ Jerusalem, Hadassah Med Ctr, Dept Med, Gastroenterol Unit, POB 12000, IL-91120 Jerusalem, Israel
[2] Hebrew Univ Jerusalem, Hadassah Med Ctr, Dept Med, Liver Unit, POB 12000, IL-91120 Jerusalem, Israel
[3] Hebrew Univ Jerusalem, Hadassah Med Ctr, Dept Nephrol, Jerusalem, Israel
来源：
HEMODIALYSIS INTERNATIONAL | 2017年 / 21卷 / 03期
关键词：
Gut microbiome; chronic renal failure; bacterial translocation; ALL-CAUSE MORTALITY; INDOXYL SULFATE; UREMIC TOXINS; OXIDATIVE STRESS; SERUM-LEVELS; ENDOTHELIAL DYSFUNCTION; BACTERIAL TRANSLOCATION; CARDIOVASCULAR-DISEASE; INTESTINAL MICROBIOTA; PERITONEAL-DIALYSIS;
D O I：
10.1111/hdi.12486
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Evidence is accumulating to consider the gut microbiome as a central player in the gut-kidney axis. Microbiome products, such as advanced glycation end products, phenols, and indoles, are absorbed into the circulation but are cleared by normal-functioning kidneys. These products then become toxic and contribute to the uremic load and to the progression of chronic kidney failure. In this review, we discuss the gut-kidney interaction under the state of chronic kidney failure as well as the potential mechanisms by which a change in the gut flora (termed gut dysbiosis) in chronic kidney disease (CKD) exacerbates uremia and leads to further progression of CKD and inflammation. Finally, the potential therapeutic interventions to target the gut microbiome in CKD are discussed.
引用
收藏
页码：323 / 334
页数：12
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