Antimicrobial Natural Products Produced by Soil-Derived Fungus Penicillium cremeogriseum W1-1

被引：1
|
作者：
Sang, Xu-Yan [1 ,2 ]
Wang, Zhao-Jie [1 ]
Yang, Ya-Bin [1 ]
Wang, Yong-Liang [1 ,2 ]
Xiang, Mei-Ling [1 ]
Zhu, Dou-Ying [1 ]
Zhou, Ying [1 ]
Luo, Xiao-Dong [1 ]
Zhao, Li-Xing [1 ,2 ]
机构：
[1] Yunnan Univ, Yunnan Res & Dev Ctr Nat Prod, Key Lab Med Chem Nat Resource, Sch Chem Sci & Technol,Minist Educ, Kunming 650091, Yunnan, Peoples R China
[2] Yunnan Univ, Coll Life Sci, Yunnan Inst Microbiol, Kunming 650091, Yunnan, Peoples R China
来源：
INDIAN JOURNAL OF MICROBIOLOGY | 2021年 / 61卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Antimicrobial activities; Preliminary mechanisms; Soil-derived fungus; INDOLE-DITERPENOIDS;
D O I：
10.1007/s12088-021-00957-z
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Ten compounds (1-10) were obtained from soil-derived Penicillium cremeogriseum W1-1 with the antimicrobial guided isolation procedure. Among them, 4 presented broad-spectrum antimicrobial activities and its preliminary mechanisms were evaluated. Compound 4 showed growth inhibition on drug-resistant pathogenic strains Escherichia coli and Candida albicans with post-contact effect (PCE), changed the morphology and membrane structure, killed cells with leakage, inhibited the growth of C. albicans by eradicating biofilms. Interestingly, the fraction containing 4 presented in vivo anti-pathogenic activities in mice, indicating this indole diterpenoid alkaloid could been used as potential antimicrobial agent.
引用
收藏
页码：519 / 523
页数：5
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