Longitudinal effects of aging on 18F-FDG distribution in cognitively normal elderly individuals

被引：33

作者：

Ishibashi, Kenji ^{[1
]}

Onishi, Airin ^{[1
]}

Fujiwara, Yoshinori ^{[2
]}

Oda, Keiichi ^{[1
,3
]}

Ishiwata, Kiichi ^{[1
,4
,5
]}

Ishii, Kenji ^{[1
]}

机构：

[1] Tokyo Metropolitan Inst Gerontol, Res Team Neuroimaging, Tokyo, Japan

[2] Tokyo Metropolitan Inst Gerontol, Res Team Social Participat & Community Hlth, Tokyo, Japan

[3] Hokkaido Univ Sci, Fac Hlth Sci, Sapporo, Hokkaido, Japan

[4] Southern Tohoku Res Inst Neurosci, Inst Cyclotron & Drug Discovery Res, Koriyama, Fukushima, Japan

[5] Fukushima Med Univ, Dept Biofunct Imaging, Fukushima, Japan

来源：

SCIENTIFIC REPORTS | 2018年 / 8卷

关键词：

POSITRON-EMISSION-TOMOGRAPHY; POSTERIOR CINGULATE CORTEX; DEFAULT MODE NETWORK; ALZHEIMERS-DISEASE; METABOLIC-RATE; BRAIN; GLUCOSE; DECLINE; IMPAIRMENT; DEMENTIA;

D O I：

10.1038/s41598-018-29937-y

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Previous studies of aging effects on fluorine-18-labeled fluorodeoxyglucose (F-18-FDG) distribution have employed cross-sectional designs. We examined aging effects on F-18-FDG distribution using both cross-sectional and longitudinal assessments. We obtained two F-18-FDG positron emission tomography scans at two different time points from 107 cognitively normal elderly participants. The participants' mean ages at baseline and second scans were 67.9 and 75.7, respectively. The follow-up period ranged from 4 to 11 years with a mean of 7.8 years. The voxel-wise analysis revealed significant clusters in which F-18-FDG uptake was decreased between baseline and second scans (p < 0.05, family-wise error corrected) in the anterior cingulate cortex (ACC), posterior cingulate cortex/precuneus (PCC/PC), and lateral parietal cortex (LPC). The cross-sectional analysis of F-18-FDG uptake and age showed significant correlations in the ACC (p = 0.016) but not the PCC/PC (p = 0.240) at baseline, and in the ACC (p = 0.004) and PCC/PC (p = 0.002) at the second scan. The results of longitudinal assessments suggested that F-18-FDG uptake in the ACC, PCC/PC, and LPC decreased with advancing age in cognitively normal elderly individuals, and those of the cross-sectional assessments suggested that the trajectories of age-associated 18F-FDG decreases differed between the ACC and PCC/PC.

引用

页数：8

共 41 条

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Yoshizawa, Hiroshi ;

Gazes, Yunglin ;

Stern, Yaakov ;

Miyata, Yoko ;

Uchiyama, Shinichiro .

PSYCHIATRY RESEARCH-NEUROIMAGING, 2014, 221 (01) :78-85

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