Synthesis of a selenocysteine-containing peptide by native chemical ligation

被引：177

作者：

Gieselman, MD ^{[1
]}

Xie, LL ^{[1
]}

van der Donk, WA ^{[1
]}

机构：

[1] Univ Illinois, Dept Chem, Urbana, IL 61801 USA

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 09期

关键词：

D O I：

10.1021/ol015712o

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A new method for the synthesis of selenocysteine derivatives and selenocysteine-containing peptides is described. Fmoc-Sep methoxybenzylselenocysteine (1) was prepared and used for solid-phase synthesis of peptides with an N-terminal unprotected selenocysteine, Subsequent native chemical ligation with a peptide thioester provided a 17-mer that corresponds to the C-terminus of ribonucleotide reductase with selenocysteine in place of cysteine.

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页码：1331 / 1334

页数：4

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