IL-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation

被引：683

作者：

Hurst, SM

Wilkinson, TS

McLoughlin, RM

Jones, S ^{[1
]}

Horiuchi, S

Yamamoto, N

Rose-John, S

Fuller, GM

Topley, N

Jones, SA ^{[1
]}

机构：

[1] Cardiff Univ, Cardiff Sch Biosci, Cardiff CF10 3US, S Glam, Wales

[2] Univ Wales Coll Med, Inst Nephrol, Cardiff CF14 4XN, S Glam, Wales

[3] Tokyo Med & Dent Univ, Dept Microbiol, Tokyo 113, Japan

[4] Univ Kiel, Kiel Inst Biochem, D-24098 Kiel, Germany

[5] Univ Alabama, Dept Cell Biol, Birmingham, AL 35294 USA

来源：

IMMUNITY | 2001年 / 14卷 / 06期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1016/S1074-7613(01)00151-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

During acute inflammation, leukocyte recruitment is characterized by an initial infiltration of neutrophils, which are later replaced by a more sustained population of mononuclear cells. Based on both clinical and experimental evidence, we present a role for IL-6 and its soluble receptor (sIL-6R) in controlling this pattern of leukocyte recruitment during peritoneal inflammation. Liberation of sIL-6R from the initial neutrophil infiltrate acts as a regulator of CXC and CC chemokine expression, which contributes to a suppression of neutrophil recruitment and the concurrent attraction of mononuclear leukocytes. Soluble IL-6R-mediated signaling is therefore an important intermediary in the resolution of inflammation and supports transition between the early predominantly neutrophilic stage of an infection and the more sustained mononuclear cell influx.

引用

页码：705 / 714

页数：10

共 37 条

[1] Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation:: Evidence in Crohn disease and experimental colitis in vivo [J].