Collagen type XVI expression is modulated by basic fibroblast growth factor and transforming growth factor-β

被引：22

作者：

Grässel, S

Tan, EML

Timpl, R

Chu, ML

机构：

[1] Thomas Jefferson Univ, Dept Dermatol & Cutaneous Biol, Philadelphia, PA 19107 USA

[2] Thomas Jefferson Univ, Dept Pathol Anat & Cell Biol, Philadelphia, PA 19107 USA

[3] Max Planck Inst, Dept Prot Chem, Martinsried, Germany

[4] Thomas Jefferson Univ, Dept Biochem & Mol Pharmacol, Philadelphia, PA 19107 USA

来源：

FEBS LETTERS | 1998年 / 436卷 / 02期

关键词：

transforming growth factor-beta; basic fibroblast growth factor; collagen XVI; arterial smooth muscle cell; dermal fibroblast;

D O I：

10.1016/S0014-5793(98)01122-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We investigated the effects of bFGF and TGF-beta on the expression of type XVI collagen, a member of the fibril associated collagen family, in human dermal fibroblasts and arterial smooth muscle cells. We found that bFGF decreased the alpha 1(XVI) collagen mRNA to 18-24% of the controls, while TGF-beta increased the mRNA to 150-360%, Immunoprecipitation of metabolically labeled cells revealed corresponding, but less pronounced, changes at the protein levels. The results suggested that type XVI collagen expression is regulated by bFGF and TGF-beta in a manner similar to their regulation of the major type I fibrillar collagen produced bg these cells. (C) 1998 Federation of European Biochemical Societies.

引用

页码：197 / 201

页数：5

共 25 条

[1] Regulation of human interstitial collagenase (matrix metalloproteinase-1) promoter activity by fibroblast growth factor
Aho, S
Rouda, S
Kennedy, SH
Qin, HP
Tan, EML
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1997, 247 (02): : 503 - 510
[2] BORNSTEIN P, 1989, PROG NUCLEIC ACID RE, V37, P67
[3] THE COLLAGEN SUPERFAMILY
BROWM, JC
TIMPL, R
[J]. INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 1995, 107 (04) : 484 - 490
[4] An AP-1 binding sequence is essential for regulation of the human alpha 2(I) collagen (COL1A2) promoter activity by transforming growth factor-beta
Chung, KY
Agarwal, A
Uitto, J
Mauviel, A
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (06) : 3272 - 3278
[5] GRANDE J, 1993, LAB INVEST, V69, P387
[6] Biosynthesis and processing of type XVI collagen in human fibroblasts and smooth muscle cells
Grassel, S
Timpl, R
Tan, EML
Chu, ML
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1996, 242 (03): : 576 - 584
[7] EFFECT OF TRANSFORMING GROWTH-FACTOR-BETA ON COLLAGEN TYPE-VI EXPRESSION IN HUMAN DERMAL FIBROBLASTS
HECKMANN, M
AUMAILLEY, M
CHU, ML
TIMPL, R
KRIEG, T
[J]. FEBS LETTERS, 1992, 310 (01) : 79 - 82
[8] INAGAKI Y, 1994, J BIOL CHEM, V269, P14828
[9] KENNEDY SH, 1995, AM J PATHOL, V146, P764
[10] LAWRENCE R, 1994, J BIOL CHEM, V269, P9603

← 1 2 3 →