Dynamics of transcription and mRNA export

被引:40
作者
Darzacq, X
Singer, RH
Shav-Tal, Y
机构
[1] Albert Einstein Coll Med, Dept Anat & Struct Biol, Bronx, NY 10461 USA
[2] Albert Einstein Coll Med, Dept Cell Biol, Bronx, NY 10461 USA
[3] Ecole Normale Super, CNRS, UMR 8541, F-75230 Paris, France
关键词
D O I
10.1016/j.ceb.2005.04.004
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Understanding the different molecular mechanisms responsible for gene expression has been a central interest of molecular biologists for several decades. Transcription, the initial step of gene expression, consists of converting the genetic code into a dynamic messenger RNA that will specify a required cellular function following translocation to the cytoplasm and translation. We now possess an in-depth understanding of the mechanism and regulations of transcription. By contrast, an understanding of the dynamics of an individual gene's expression in real time is just beginning to emerge following recent technological developments.
引用
收藏
页码:332 / 339
页数:8
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共 69 条
  • [11] Chromosome territories, nuclear architecture and gene regulation in mammalian cells
    Cremer, T
    Cremer, C
    [J]. NATURE REVIEWS GENETICS, 2001, 2 (04) : 292 - 301
  • [12] Single-molecule study of transcriptional pausing and arrest by E-coli RNA polymerase
    Davenport, RJ
    Wuite, GJL
    Landick, R
    Bustamante, C
    [J]. SCIENCE, 2000, 287 (5462) : 2497 - 2500
  • [13] Dynamic repositioning of CD4 and CD8 genes during T cell development
    Delaire, S
    Huang, YH
    Chan, SW
    Robey, EA
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 200 (11) : 1427 - 1435
  • [14] Messenger-RNA-binding proteins and the messages they carry
    Dreyfuss, G
    Kim, VN
    Kataoka, N
    [J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2002, 3 (03) : 195 - 205
  • [15] A kinetic framework for a mammalian RNA polymerase in vivo
    Dundr, M
    Hoffmann-Rohrer, U
    Hu, QY
    Grummt, I
    Rothblum, LI
    Phair, RD
    Misteli, T
    [J]. SCIENCE, 2002, 298 (5598) : 1623 - 1626
  • [16] Stochastic gene expression in a single cell
    Elowitz, MB
    Levine, AJ
    Siggia, ED
    Swain, PS
    [J]. SCIENCE, 2002, 297 (5584) : 1183 - 1186
  • [17] The nuclear pore complex: Nucleocytoplasmic transport and beyond
    Fahrenkrog, B
    Aebi, U
    [J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2003, 4 (10) : 757 - 766
  • [18] Visualization of single RNA transcripts in situ
    Femino, A
    Fay, FS
    Fogarty, K
    Singer, RH
    [J]. SCIENCE, 1998, 280 (5363) : 585 - 590
  • [19] Noise minimization in eukaryotic gene expression
    Fraser, HB
    Hirsh, AE
    Giaever, G
    Kumm, J
    Eisen, MB
    [J]. PLOS BIOLOGY, 2004, 2 (06): : 834 - 838
  • [20] Single mRNA molecules demonstrate probabilistic movement in living mammalian cells
    Fusco, D
    Accornero, N
    Lavoie, B
    Shenoy, SM
    Blanchard, JM
    Singer, RH
    Bertrand, E
    [J]. CURRENT BIOLOGY, 2003, 13 (02) : 161 - 167