Dynamics of transcription and mRNA export

被引:40
作者
Darzacq, X
Singer, RH
Shav-Tal, Y
机构
[1] Albert Einstein Coll Med, Dept Anat & Struct Biol, Bronx, NY 10461 USA
[2] Albert Einstein Coll Med, Dept Cell Biol, Bronx, NY 10461 USA
[3] Ecole Normale Super, CNRS, UMR 8541, F-75230 Paris, France
关键词
D O I
10.1016/j.ceb.2005.04.004
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Understanding the different molecular mechanisms responsible for gene expression has been a central interest of molecular biologists for several decades. Transcription, the initial step of gene expression, consists of converting the genetic code into a dynamic messenger RNA that will specify a required cellular function following translocation to the cytoplasm and translation. We now possess an in-depth understanding of the mechanism and regulations of transcription. By contrast, an understanding of the dynamics of an individual gene's expression in real time is just beginning to emerge following recent technological developments.
引用
收藏
页码:332 / 339
页数:8
相关论文
共 69 条
  • [1] Single molecule analysis of RNA polymerase elongation reveals uniform kinetic behavior
    Adelman, K
    La Porta, A
    Santangelo, TJ
    Lis, JT
    Roberts, JW
    Wang, MD
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (21) : 13538 - 13543
  • [2] In vivo kinetics of mRNA splicing and transport in mammalian cells
    Audibert, A
    Weil, D
    Dautry, F
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (19) : 6706 - 6718
  • [3] Dynamic behavior of transcription factors on a natural promoter in living cells
    Becker, M
    Baumann, C
    John, S
    Walker, DA
    Vigneron, M
    McNally, JG
    Hager, GL
    [J]. EMBO REPORTS, 2002, 3 (12) : 1188 - 1194
  • [4] Localization of ASH1 mRNA particles in living yeast
    Bertrand, E
    Chartrand, P
    Schaefer, M
    Shenoy, SM
    Singer, RH
    Long, RM
    [J]. MOLECULAR CELL, 1998, 2 (04) : 437 - 445
  • [5] Noise in eukaryotic gene expression
    Blake, WJ
    Kærn, M
    Cantor, CR
    Collins, JJ
    [J]. NATURE, 2003, 422 (6932) : 633 - 637
  • [6] Nuclear RNAs confined to a reticular compartment between chromosome territories
    Bridger, JM
    Kalla, C
    Wodrich, H
    Weitz, S
    King, JA
    Khazaie, K
    Kräusslich, HG
    Lichter, P
    [J]. EXPERIMENTAL CELL RESEARCH, 2005, 302 (02) : 180 - 193
  • [7] The intranuclear mobility of messenger RNA binding proteins is ATP dependent and temperature sensitive
    Calapez, A
    Pereira, HM
    Calado, A
    Braga, J
    Rino, J
    Carvalho, C
    Tavanez, JP
    Wahle, E
    Rosa, AC
    Carmo-Fonseca, M
    [J]. JOURNAL OF CELL BIOLOGY, 2002, 159 (05) : 795 - 805
  • [8] Genome-wide localization of the nuclear transport machinery couples transcriptional status and nuclear organization
    Casolari, JM
    Brown, CR
    Komili, S
    West, J
    Hieronymus, H
    Silver, PA
    [J]. CELL, 2004, 117 (04) : 427 - 439
  • [9] Unbiased mapping of transcription factor binding sites along human chromosomes 21 and 22 points to widespread regulation of noncoding RNAs
    Cawley, S
    Bekiranov, S
    Ng, HH
    Kapranov, P
    Sekinger, EA
    Kampa, D
    Piccolboni, A
    Sementchenko, V
    Cheng, J
    Williams, AJ
    Wheeler, R
    Wong, B
    Drenkow, J
    Yamanaka, M
    Patel, S
    Brubaker, S
    Tammana, H
    Helt, G
    Struhl, K
    Gingeras, TR
    [J]. CELL, 2004, 116 (04) : 499 - 509
  • [10] RNA polymerase II structure: from core to functional complexes
    Cramer, P
    [J]. CURRENT OPINION IN GENETICS & DEVELOPMENT, 2004, 14 (02) : 218 - 226