Withanolides from Leaves of Nicandra physalodes

被引：10

作者：

Carrero, Diego A. S. ^{[1
]}

Batista, Pedro H. J. ^{[1
]}

Souza, Luciana G. S. ^{[1
]}

Pinto, Francisco C. L. ^{[1
]}

de Vasconcelos, Mayron A. ^{[2
]}

Teixeira, Edson H. ^{[2
]}

Canuto, Kirley M. ^{[3
]}

Santiago, Gilvandete M. P. ^{[1
]}

Silveira, Edilberto R. ^{[1
]}

Pessoa, Otilia D. L. ^{[1
]}

机构：

[1] Univ Fed Ceara, Ctr Ciencias, Dept Quim Organ & Inorgan, BR-60021970 Fortaleza, Ceara, Brazil

[2] Univ Fed Ceara, Dept Patol & Med Legal, Lab Integrado Biomol LIBS, BR-60441750 Fortaleza, Ceara, Brazil

[3] Embrapa Agroind Trop, R Dra Sara Mesquita 2270, BR-60511110 Fortaleza, Ceara, Brazil

来源：

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | 2018年 / 29卷 / 01期

关键词：

Nicandra physalodes; Solanaceae; withanolides;

D O I：

10.21577/0103-5053.20170105

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Five new withanolides, designated as 15-oxo-nicaphysalin B, 6 beta, 7 alpha-dihydroxynicandrenone 10, 24 alpha, 25 beta-dihydroxy-nicandrenone-2 and a mixture of the epimers 17-(1 alpha/1 beta-methylpropanone)-nicandrenone, in addition to six known others, were isolated from the leaf acetone extract from Nicandra physalodes. The complete structures of the five new withanolides, particularly their relative stereochemistries, were established by extensive spectroscopic analyses, including 1D and 2D nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectrometry (HRESIMS). The main isolated withanolides were evaluated for their antibacterial, antifungal and larvicidal properties, but, except nicandrenone, which showed marginal larvicidal activity, none of them was active.

引用

页码：11 / 16

页数：6

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