Palladium-Catalyzed Cascade Cyclization/Alkynylation of Alkene-tethered Carbamoyl Chlorides with Terminal Alkynes: Synthesis of Alkyne-functionalized Oxindoles

被引：23

作者：

Sun, Wan ^{[1
]}

Shi, Xiaonan ^{[1
]}

Chen, Chen ^{[1
]}

Zhu, Yan-Ping ^{[2
]}

Liu, Zhengyu ^{[1
]}

Zhu, Bolin ^{[1
]}

机构：

[1] Tianjin Normal Univ, Coll Chem, Tianjin Key Lab Struct & Performance Funct Mol, Tianjin 300387, Peoples R China

[2] Yantai Univ, Collaborat Innovat Ctr Adv Drug Delivery Syst & B, Minist Educ, Key Lab Mol Pharmacol & Drug Evaluat,Sch Pharm, Yantai 264005, Shandong, Peoples R China

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 9卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Oxindoles; Carbamoyl Chlorides; Palladium; Heck; Sonogashira Coupling; Alkynes; OXIME ESTERS SYNTHESIS; C-H ACTIVATION; IN-VITRO; HECK CYCLIZATION; LIPOSOMES; DESIGN; ROUTE;

D O I：

10.1002/ajoc.202000033

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We reported the first palladium-catalyzed copper-free cascade cyclization/alkynylation of alkene-tethered carbamoyl chlorides with terminal alkynes, which provided an alternative approach to synthesize various functionalized oxindoles bearing a propargyl all-carbon quaternary center. This protocol was highly efficient and exhibited good functional group compatibility, as well as the broad substrate scope.

引用

页码：575 / 578

页数：4

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