Terminal-Selective C(sp3)-H Arylation: NiH-Catalyzed Remote Hydroarylation of Unactivated Internal Olefins

被引：15
作者：
He, Yuli [1 ]
Han, Bo [1 ]
Zhu, Shaolin [1 ]
机构：
[1] Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Coordinat Chem, Chem & Biomed Innovat Ctr ChemBIC,Jiangsu Key Lab, Nanjing 210093, Peoples R China
来源：
ORGANOMETALLICS | 2021年 / 40卷 / 14期
关键词：
ALKENE ISOMERIZATION-HYDROBORATION; ANTI-MARKOVNIKOV HYDROARYLATION; SECONDARY ALKYL ELECTROPHILES; CROSS-COUPLINGS; PALLADIUM; FUNCTIONALIZATION; HALIDES; CARBOXYLATION; HYDROCARBONS; MECHANISM;
D O I：
10.1021/acs.organomet.0c00819
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A terminal-selective migratory hydroarylation of unactivated olefins has been developed though a NiH-catalyzed alkene isomerization-hydroarylation relay process. This sp(3) C-H arylation was achieved with a simple pyrox ligand under mild conditions. The practicality and synthetic flexibility of the method is highlighted by the successful regioconvergent conversion of isomeric mixtures of alkenes to value-added linear arylation products on a gram scale.
引用
收藏
页码：2253 / 2264
页数：12
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