Stability of small mesoporous silica nanoparticles in biological media

被引：141
|
作者：
Lin, Yu-Shen [1 ]
Abadeer, Nardine [1 ]
Haynes, Christy L. [1 ]
机构：
[1] Univ Minnesota, Dept Chem, Minneapolis, MN 55455 USA
来源：
CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 01期
关键词：
SIZE; FUNCTIONALIZATION; SYSTEM;
D O I：
10.1039/c0cc02923h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In this work, sub-50 nm pegylated mesoporous silica nanoparticles prepared with hydrothermal treatment are shown to have long-term stability in various media at both room and physiological temperature. Compared to bare mesoporous silica nanoparticles, the highly pegylated mesoporous silica nanoparticles show significantly improved biocompatibility and decreased macrophage uptake, making these nanoparticles viable for in vivo stealth drug delivery applications.
引用
收藏
页码：532 / 534
页数：3
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