STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells

被引：72

作者：

Onodera, Atsushi ^{[1
]}

Yamashita, Masakatsu ^{[1
]}

Endo, Yusuke ^{[1
]}

Kuwahara, Makoto ^{[1
]}

Tofukuji, Soichi ^{[1
]}

Hosokawa, Hiroyuki ^{[1
]}

Kanai, Akinori ^{[2
]}

Suzuki, Yutaka ^{[2
]}

Nakayama, Toshinori ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Med, Dept Immunol, Chuo Ku, Chiba 2608670, Japan

[2] Univ Tokyo, Grad Sch Frontier Sci, Dept Med Genome Sci, Lab Funct Genom, Kashiwa, Chiba 2778562, Japan

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2010年 / 207卷 / 11期

关键词：

TRANSCRIPTION FACTOR GATA-3; RNA-POLYMERASE-II; GENE-EXPRESSION; METHYLTRANSFERASE COMPLEX; HISTONE METHYLTRANSFERASE; INTERLEUKIN-4; RECEPTOR; DNA-BINDING; ROR-GAMMA; DIFFERENTIATION; MEMORY;

D O I：

10.1084/jem.20100760

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Polycomb group (PcG) and trithorax group (TrxG) complexes exert opposing effects on the maintenance of the transcriptional status of the developmentally regulated Hox genes. In this study, we show that activation of STAT6 induces displacement of the PcG complex by the TrxG complex at the upstream region of the gene encoding GATA3, a transcription factor essential for T helper type 2 (Th2) cell differentiation. Once Th2 cells differentiate, TrxG complex associated with the TrxG component Menin binds to the whole GATA3 gene locus, and this binding is required for the long-term maintenance of expression of GATA3 and Th2 cytokine. Thus, STAT6-mediated displacement of PcG by the TrxG complex establishes subsequent STAT6-independent maintenance of GATA3 expression in Th2 cells via the recruitment of the Menin-TrxG complex.

引用

页码：2493 / 2506

页数：14

共 48 条

[1] Direct regulation of Gata3 expression determines the T helper differentiation potential of notch [J].