Trained immunity modulates inflammation-induced fibrosis

被引：109

作者：

Jeljeli, Mohamed ^{[1
,2
]}

Coelho Riccio, Luiza Gama ^{[1
,3
]}

Doridot, Ludivine ^{[1
]}

Chene, Charlotte ^{[1
]}

Nicco, Carole ^{[1
]}

Chouzenoux, Sandrine ^{[1
]}

Deletang, Quentin ^{[1
]}

Allanore, Yannick ^{[1
,4
]}

Kavian, Niloufar ^{[1
,2
,5
]}

Batteux, Frederic ^{[1
,2
]}

机构：

[1] Univ Paris 05, Inst Cochin, INSERM, Sorbonne Paris Cite,U1016, Paris, France

[2] Ctr Hosp Univ CHU Cochin, HUPC, AP HP, Serv Immunol Biol, Paris, France

[3] Univ Sao Paulo, Dept Obstet & Ginecol, Disciplina Ginecol, Fac Med FMUSP, Sao Paulo, SP, Brazil

[4] Ctr Hosp Univ CHU Cochin, HUPC, AP HP, Serv Rhumatol, Paris, France

[5] Univ Hong Kong, Hong Kong Univ Pasteur Res Pole0, Sch Publ Hlth, Hong Kong, Peoples R China

来源：

NATURE COMMUNICATIONS | 2019年 / 10卷 / 1期

关键词：

INDUCED PULMONARY-FIBROSIS; SYSTEMIC-SCLEROSIS; MACROPHAGE INFILTRATION; CIRCULATING MONOCYTES; INNATE IMMUNITY; SKIN FIBROSIS; TGF-BETA; ACTIVATION; LUNG; FIBROBLASTS;

D O I：

10.1038/s41467-019-13636-x

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Chronic inflammation and fibrosis can result from inappropriately activated immune responses that are mediated by macrophages. Macrophages can acquire memory-like characteristics in response to antigen exposure. Here, we show the effect of BCG or low-dose LPS stimulation on macrophage phenotype, cytokine production, chromatin and metabolic modifications. Low-dose LPS training alleviates fibrosis and inflammation in a mouse model of systemic sclerosis (SSc), whereas BCG-training exacerbates disease in this model. Adoptive transfer of low-dose LPS-trained or BCG-trained macrophages also has beneficial or harmful effects, respectively. Furthermore, coculture with low-dose LPS trained macrophages reduces the fibro-inflammatory profile of fibroblasts from mice and patients with SSc, indicating that trained immunity might be a phenomenon that can be targeted to treat SSc and other autoimmune and inflammatory fibrotic disorders.

引用

页数：15

共 86 条

[1] Dysregulated Toll-Like Receptor-Induced Interleukin-1β and Interleukin-6 Responses in Subjects at Risk for the Development of Type 1 Diabetes [J].