Apoptotic PET Imaging of Rat Pulmonary Fibrosis With [18F]ML-8

被引：6
|
作者：
Xiong, Ying [1 ,2 ]
Nie, Dahong [1 ,2 ]
Liu, Shaoyu [1 ,2 ]
Ma, Hui [1 ,2 ]
Su, Shu [1 ,2 ]
Sun, Aixia [1 ,2 ]
Zhao, Jing [1 ,2 ]
Zhang, Zhanwen [1 ,2 ]
Xiang, Xianhong [1 ,2 ]
Tang, Ganghua [1 ,2 ]
机构：
[1] Sun Yat Sen Univ, Affiliated Hosp 1, Guangdong Engn Res Ctr Translat Applicat Med Radi, Guangzhou 510080, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Med Imaging, Guangzhou 510080, Guangdong, Peoples R China
来源：
MOLECULAR IMAGING | 2018年 / 17卷
基金：
中国国家自然科学基金;
关键词：
pulmonary fibrosis; diagnosis; PET/CT; F-18]ML-8; F-18]FDG; POSITRON-EMISSION-TOMOGRAPHY; INTERSTITIAL PNEUMONIA; F-18-FDG; DIAGNOSIS; ANALOG; MICE;
D O I：
10.1177/1536012118795728
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Objective: To investigate the value of 2-(3-[F-18]fluoropropyl)-2-methyl-nnalonic acid ([F-18]ML-8) positron emission tomography (PET) imaging of rat pulmonary fibrosis. Methods: Male Sprague-Dawley rats were divided into 2 groups, including pulmonary fibrosis model group and control group. The rat model was established by an intratracheal instillation of bleomycin (BLM). Control rats were treated with saline. Positron emission tomography/computed tomography (CT) with [F-18]ML-8 or F-18-fluorodeoxyglucose ([F-18]FDG) was performed on 2 groups. After PET/CT imaging, lung tissues were collected for histologic examination. Data were analyzed and comparisons between 2 groups were performed using Student t test. Results: Bleomycin-treated rats showed a higher lung uptake of [F-18]ML-8 than control rats (P < .05). In BLM-treated rats, the lung to muscle relative uptake ratio of [F-18]ML-8 was also higher than that of [F-18]FDG (P < .05). Pathological examination showed overproliferation of fibroblasts and deposition of collagen in lungs from BLM-treated rats. Compared to control rats, BLM-treated rats had higher lung hydroxyproline content (P < .05). Immunofluorescence staining indicated more apoptotic cells in BLM-treated rats than those in control rats. Moreover, the apoptosis rate of lung tissues obtained from BLM-treated rats was higher than that from control rats (P < .05). Conclusions: 2-(3-[F-18]fluoropropyl)-2-methyl-nnalonic acid PET/CT could be used for noninvasive diagnosis of pulmonary fibrosis in a rat model.
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页数：8
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