Self-immolative chemistry in nanomedicine

被引：40

作者：

Gisbert-Garzaran, M.

Manzano, M. ^{[1
]}

Vallet-Regi, M. ^{[1
]}

机构：

[1] Univ Complutense Madrid, Hosp 12 Octubre I 12, Inst Invest Sanitaria, Dept Quim Inorgan & Bioinorgan,Fac Farm, Plaza Ramon y Cajal S-N, E-28040 Madrid, Spain

来源：

CHEMICAL ENGINEERING JOURNAL | 2018年 / 340卷

基金：

欧盟地平线“2020”; 欧洲研究理事会;

关键词：

Self-immolative; Nanomedicine; Mesoporous silica nanoparticles; Polymer nanoparticles; Prodrugs; MESOPOROUS SILICA NANOPARTICLES; DRUG-DELIVERY; CATHEPSIN-B; INTRAMOLECULAR CYCLIZATION; POLYMERIC MICELLES; PRODRUG; RELEASE; DESIGN; DEPOLYMERIZATION; DEGRADATION;

D O I：

10.1016/j.cej.2017.12.098

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Self-immolative chemistry is based on the cascade of disassembling reactions triggered by the adequate stimulation and leading to the sequential release of the smaller constituent elements. This review will focus on the possibilities that this type of chemistry offers to nanomedicine research, which is an area where the stimuli responsive behavior is always targeted. There are some examples on the use of self-immolative chemistry for prodrugs or nanoparticles for drug delivery, but there is still an exciting land of opportunities waiting to be explored. This review aims at revising what has been done so far, but, most importantly, it aims at inspiring new research of self-immolative chemistry on nanomedicine.

引用

页码：24 / 31

页数：8

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