Protostane-Type Triterpenoids from Alisma orientale

被引：16

作者：

Li, Hong-Mei ^{[1
,2
]}

Chen, Xue-Jiao ^{[1
]}

Luo, Dan ^{[1
]}

Fan, Min ^{[1
]}

Zhang, Zhi-Jun ^{[1
]}

Peng, Li-Yan ^{[1
]}

Wu, Xing-De ^{[1
]}

Li, Rong-Tao ^{[2
]}

Ji, Xu ^{[1
]}

Zhao, Qin-Shi ^{[1
]}

机构：

[1] Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China

[2] Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming 650500, Yunnan, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2017年 / 14卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Alisma orientale; Alismatis Rhizoma; Alismataceae; Protostane triterpenoids; Vasorelaxant activity; 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; NOR-DAMMARANE TRITERPENOIDS; ABSOLUTE STEREOSTRUCTURES; 11-BETA-HSD1; INHIBITORS; DYSOXYLUM-HAINANENSE; METABOLIC SYNDROME; RHIZOMA; 23-ACETATE; SESQUITERPENES; DITERPENOIDS;

D O I：

10.1002/cbdv.201700452

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Twenty-eight protostane triterpenoids, including a new degraded one (1), nine new ones (2 - 10), and two new natural ones (11 and 12), have been isolated from the dried rhizomes of Alisma orientale. Alisol R (1) was the first 20,21,22,23,24,25,26,27-octanorprotostane triterpenoid. The absolute configurations of 25-methoxyalisol F (2) and 16-hydroperoxyalisol B 23-acetate (3) were determined by X-ray diffraction analysis. In addition, alismaketone-B 23-acetate (28) showed potent vasorelaxant activity on endothelium-intact thoracic aorta rings precontracted with KCl.

引用

页数：13

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