Mucoadhesion evaluation of polysaccharide gels for vaginal application by using rheological and indentation measurements

被引：13
作者：
Pliszczak, D. [1 ,2 ]
Bordes, C. [1 ]
Bourgeois, S. [2 ]
Marote, P. [1 ]
Zahouani, H. [3 ]
Tupin, S. [3 ]
Pailler-Mattei, C. [3 ,4 ]
Lanteri, P. [1 ]
机构：
[1] Univ Lyon 1, UMR 5180, Sci Analyt Lab, F-69622 Villeurbanne, France
[2] Univ Lyon 1, UMR CNRS 5007, Lab Automat & Genie Procedes LAGEP, F-69622 Villeurbanne, France
[3] Univ Lyon, Ecole Cent Lyon, Lab Tribol & Dynam Syst, UMR CNRS 5513, Ecully, France
[4] Univ Lyon, Fac Pharm ISPB, Biophys Lab, F-69003 Lyon, France
来源：
COLLOIDS AND SURFACES B-BIOINTERFACES | 2012年 / 92卷
关键词：
Low methyl pectin gel; Hyaluronic acid; Fructooligosaccharides; Dynamic rheological measurements; Bio-adhesion measurements; Mucoadhesive microparticles; IN-VITRO EVALUATION; DRUG-DELIVERY; MECHANICAL-PROPERTIES; PECTIN; MUCIN; TEMPERATURE; POLYMERS; SYSTEMS; MICROSTRUCTURE; BEHAVIOR;
D O I：
10.1016/j.colsurfb.2011.11.039
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
The influence of hyaluronic acid (HA) and fructooligosaccharides (FOS) addition on low methyl pectin (LMP) gelation has been investigated in order to produce adhesive gel-based microparticles suitable for the development of a vaginal delivery system of pro- and prebiotics. First, dynamic rheological measurements were performed on LMP/Ca2+ gels with or without FOS and HA in presence or not of porcine stomach mucins. This rheological method is known to translate the interactions between polymer and mucins and then simulate the polymer bioadhesion potential. Nevertheless, as this method is disputed, in vitro and ex vivo indentation test measurements were also achieved in order to correlate the results obtained. Despite some different results, the overall tendency indicates that addition of HA and FOS enhanced the mucoadhesive properties of LMP gels. Moreover, gel-based microparticles obtained according to an emulsification/gelation method and composed by LMP 3% (w/v), FOS 5% (w/v) and HA 0.5% (w/v) displayed a mucoadhesive potential adapted to vaginal delivery system. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：168 / 174
页数：7
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