Osteoimmunology: Interactions of the bone and immune system

被引：418

作者：

Lorenzo, Joseph ^{[1
,2
]}

Horowitz, Mark ^{[3
]}

Choi, Yongwon ^{[4
]}

机构：

[1] Univ Connecticut, Ctr Hlth, Dept Med, Farmington, CT 06030 USA

[2] Univ Connecticut, Ctr Hlth, Musculoskeletal Inst, Farmington, CT 06030 USA

[3] Yale Univ, Sch Med, Dept Orthopaed, New Haven, CT 06510 USA

[4] Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

来源：

ENDOCRINE REVIEWS | 2008年 / 29卷 / 04期

关键词：

D O I：

10.1210/er.2007-0038

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Bone and the immune system are both complex tissues that respectively regulate the skeleton and the body's response to invading pathogens. It has now become clear that these organ systems often interact in their function. This is particularly true for the development of immune cells in the bone marrow and for the function of bone cells in health and disease. Because these two disciplines developed independently, investigators in each don't always fully appreciate the significance that the other system has on the function of the tissue they are studying. This review is meant to provide a broad overview of the many ways that bone and immune cells interact so that a better understanding of the role that each plays in the development and function of the other can develop. It is hoped that an appreciation of the interactions of these two organ systems will lead to better therapeutics for diseases that affect either or both.

引用

页码：403 / 440

页数：38

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