Circuit and synaptic mechanisms of repeated stress: Perspectives from differing contexts, duration, and development

被引:38
作者
Bath, Kevin G. [1 ]
Russo, Scott J. [2 ,3 ]
Pleil, Kristen E. [4 ]
Wohleb, Eric S. [5 ,6 ]
Duman, Ronald S. [6 ]
Radley, Jason J. [7 ]
机构
[1] Brown Univ, Dept Cognit Linguist & Psychol Sci, 180 Thayer St,Box 1821, Providence, RI 02912 USA
[2] Icahn Sch Med Mt Sinai, Fishberg Dept Neurosci, New York, NY 10029 USA
[3] Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY 10029 USA
[4] Weill Cornell Med Coll, Dept Pharmacol, New York, NY 10065 USA
[5] Univ Cincinnati, Coll Med, Dept Psychiat, Cincinnati, OH 45237 USA
[6] Yale Sch Med, Dept Psychiat, New Haven, CT 06508 USA
[7] Univ Iowa, Dept Psychol & Brain Sci, E11 Seahorse Hall, Iowa City, IA 52242 USA
关键词
Early-life stress; Hippocampus; Susceptibility; Resilience; Nucleus accumbens; Bed nuclei of the stria terminalis; Neuropeptide Y; Corticotropin-releasing factor; Prefrtonal cortex; Mammalian target of rapamycin; Major depressive disorder; CORTICOTROPIN-RELEASING-FACTOR; ADVERSE CHILDHOOD EXPERIENCES; EARLY-LIFE STRESS; REGULATE POSTNATAL-DEVELOPMENT; MEDIAL PREFRONTAL CORTEX; RAT DENTATE GYRUS; BED NUCLEUS; STRIA TERMINALIS; ETHANOL DRINKING; SEX-DIFFERENCES;
D O I
10.1016/j.ynstr.2017.05.001
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The current review is meant to synthesize research presented as part of a symposium at the 2016 Neurobiology of Stress workshop in Irvine California. The focus of the symposium was "Stress and the Synapse: New Concepts and Methods" and featured the work of several junior investigators. The presentations focused on the impact of various forms of stress (altered maternal care, binge alcohol drinking, chronic social defeat, and chronic unpredictable stress) on synaptic function, neurodevelopment, and behavioral outcomes. One of the goals of the symposium was to highlight the mechanisms accounting for how the nervous system responds to stress and their impact on outcome measures with converging effects on the development of pathological behavior. Dr. Kevin Bath's presentation focused on the impact of disruptions in early maternal care and its impact on the timing of hippocampus maturation in mice, finding that this form of stress drove accelerated synaptic and behavioral maturation, and contributed to the later emergence of risk for cognitive and emotional disturbance. Dr. Scott Russo highlighted the impact of chronic social defeat stress in adolescent mice on the development and plasticity of reward circuity, with a focus on glutamatergic development in the nucleus accumbens and mesolimbic dopamine system, and the implications of these changes for disruptions in social and hedonic response, key processes disturbed in depressive pathology. Dr. Kristen Pleil described synaptic changes in the bed nuclei of the stria terminalis that underlie the behavioral consequences of allostatic load produced by repeated cycles of alcohol binge drinking and withdrawal. Dr. Eric Wohleb and Dr. Ron Duman provided new data associating decreased mammalian target of rapamycin (mTOR) signaling and neurobiological changes in the synapses in response to chronic unpredictable stress, and highlighted the potential for the novel antidepressant ketamine to rescue synaptic and behavioral effects. In aggregate, these presentations showcased how divergent perspectives provide new insights into the ways in which stress impacts circuit development and function, with implications for understanding emergence of affective pathology. (c) 2017 Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license.
引用
收藏
页码:137 / 151
页数:15
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