Therapeutic Advances of Stem Cell-Derived Extracellular Vesicles in Regenerative Medicine

被引：67

作者：

Yin, Lei ^{[1
]}

Liu, Xiaotian ^{[1
]}

Shi, Yinghong ^{[1
]}

Ocansey, Dickson Kofi Wiredu ^{[1
]}

Hu, Yuyan ^{[1
]}

Li, Xiaoxi ^{[1
]}

Zhang, Chenxiao ^{[1
]}

Xu, Wenrong ^{[1
]}

Qian, Hui ^{[1
]}

机构：

[1] Jiangsu Univ, Zhenjiang Key Lab High Technol Res Exosomes Fdn &, Sch Med, Jiangsu Key Lab Med Sci & Lab Med, 301 Xuefu Rd, Zhenjiang 212013, Jiangsu, Peoples R China

来源：

CELLS | 2020年 / 9卷 / 03期

基金：

中国国家自然科学基金;

关键词：

stem cell; extracellular vesicle; tissue damage; regenerative medicine; MESENCHYMAL STROMAL CELLS; FUNCTIONAL RECOVERY; ONCOLYTIC ADENOVIRUS; CARDIAC-FUNCTION; LUNG INJURY; EXOSOMES; DELIVERY; REPAIR; MICROVESICLES; GROWTH;

D O I：

10.3390/cells9030707

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Extracellular vesicles (EVs), which are the main paracrine components of stem cells, mimic the regenerative capacity of these cells. Stem cell-derived EVs (SC-EVs) have been used for the treatment of various forms of tissue injury in preclinical trials through maintenance of their stemness, induction of regenerative phenotypes, apoptosis inhibition, and immune regulation. The efficiency of SC-EVs may be enhanced by selecting the appropriate EV-producing cells and cell phenotypes, optimizing cell culture conditions for the production of optimal EVs, and further engineering the EVs produced to transport therapeutic and targeting molecules.

引用

页数：28

共 114 条

[21] Graft-Versus-Host Disease Amelioration by Human Bone Marrow Mesenchymal Stromal/Stem Cell-Derived Extracellular Vesicles Is Associated with Peripheral Preservation of Naive T Cell Populations [J].

Fujii, Sumie ;

Miura, Yasuo ;

Fujishiro, Aya ;

Shindo, Takero ;

Shimazu, Yutaka ;

Hirai, Hideyo ;

Tahara, Hidetoshi ;

Takaori-Kondo, Akifumi ;

Ichinohe, Tatsuo ;

Maekawa, Taira .

STEM CELLS, 2018, 36 (03) :434-445

[22] Extracellular vesicles enhance the targeted delivery of immunogenic oncolytic adenovirus and paclitaxel in immunocompetent mice [J].

Garofalo, M. ;

Villa, A. ;

Rizzi, N. ;

Kuryk, L. ;

Rinner, B. ;

Cerullo, V ;

Yliperttula, M. ;

Mazzaferro, V ;

Ciana, P. .

JOURNAL OF CONTROLLED RELEASE, 2019, 294 :165-175

[23] Heterologous and cross-species tropism of cancer-derived extracellular vesicles [J].

Garofalo, Mariangela ;

Villa, Alessandro ;

Crescenti, Daniela ;

Marzagalli, Monica ;

Kuryk, Lukasz ;

Limonta, Patrizia ;

Mazzaferro, Vincenzo ;

Ciana, Paolo .

THERANOSTICS, 2019, 9 (19) :5681-5693

[24] Systemic Administration and Targeted Delivery of Immunogenic Oncolytic Adenovirus Encapsulated in Extracellular Vesicles for Cancer Therapies [J].

Garofalo, Mariangela ;

Villa, Alessandro ;

Rizzi, Nicoletta ;

Kuryk, Lukasz ;

Mazzaferro, Vincenzo ;

Ciana, Paolo .

VIRUSES-BASEL, 2018, 10 (10)

[25] Exosomes as Hedgehog carriers in cytoneme-mediated transport and secretion [J].

Gradilla, Ana-Citlali ;

Gonzalez, Esperanza ;

Seijo, Irene ;

Andres, German ;

Bischoff, Marcus ;

Gonzalez-Mendez, Laura ;

Sanchez, Vanessa ;

Callejo, Ainhoa ;

Ibanez, Carmen ;

Guerra, Milagros ;

Ortigao-Farias, Joao Ramalho ;

Sutherland, James D. ;

Gonzalez, Monika ;

Barrio, Rosa ;

Falcon-Perez, Juan M. ;

Guerrero, Isabel .

NATURE COMMUNICATIONS, 2014, 5

[26] Extracellular vesicles from bone marrow-derived mesenchymal stem cells protect against murine hepatic ischemia/reperfusion injury [J].

Haga, Hiroaki ;

Yan, Irene K. ;

Borrelli, David A. ;

Matsuda, Akiko ;

Parasramka, Mansi ;

Shukla, Neha ;

Lee, David D. ;

Patel, Tushar .

LIVER TRANSPLANTATION, 2017, 23 (06) :791-803

[27] Extracellular Vesicles from Bone Marrow-Derived Mesenchymal Stem Cells Improve Survival from Lethal Hepatic Failure in Mice [J].

Haga, Hiroaki ;

Yan, Irene K. ;

Takahashi, Kenji ;

Matsuda, Akiko ;

Patel, Tushar .

STEM CELLS TRANSLATIONAL MEDICINE, 2017, 6 (04) :1262-1272

[28] On the origin of microparticles: From "platelet dust" to mediators of intercellular communication [J].

Hargett, Leslie A. ;

Bauer, Natalie N. .

PULMONARY CIRCULATION, 2013, 3 (02) :329-340

[29] Optimizing oncolytic virotherapy in cancer treatment [J].

Harrington, Kevin ;

Freeman, Daniel J. ;

Kelly, Beth ;

Harper, James ;

Soria, Jean-Charles .

NATURE REVIEWS DRUG DISCOVERY, 2019, 18 (09) :689-706

[30] Inflammation-Stimulated Mesenchymal Stromal Cell-Derived Extracellular Vesicles Attenuate Inflammation [J].

Harting, Matthew T. ;

Srivastava, Amit K. ;

Zhaorigetu, Siqin ;

Bair, Henry ;

Prabhakara, Karthik S. ;

Furman, Naama E. Toledano ;

Vykoukal, Jody V. ;

Ruppert, Katherine A. ;

Cox, Charles S., Jr. ;

Olson, Scott D. .

STEM CELLS, 2018, 36 (01) :79-90

← 1 2 3 4 5 6 7 8 9 10 →