Therapeutic Advances of Stem Cell-Derived Extracellular Vesicles in Regenerative Medicine

被引：61
作者：
Yin, Lei [1 ]
Liu, Xiaotian [1 ]
Shi, Yinghong [1 ]
Ocansey, Dickson Kofi Wiredu [1 ]
Hu, Yuyan [1 ]
Li, Xiaoxi [1 ]
Zhang, Chenxiao [1 ]
Xu, Wenrong [1 ]
Qian, Hui [1 ]
机构：
[1] Jiangsu Univ, Zhenjiang Key Lab High Technol Res Exosomes Fdn &, Sch Med, Jiangsu Key Lab Med Sci & Lab Med, 301 Xuefu Rd, Zhenjiang 212013, Jiangsu, Peoples R China
来源：
CELLS | 2020年 / 9卷 / 03期
基金：
中国国家自然科学基金;
关键词：
stem cell; extracellular vesicle; tissue damage; regenerative medicine; MESENCHYMAL STROMAL CELLS; FUNCTIONAL RECOVERY; ONCOLYTIC ADENOVIRUS; CARDIAC-FUNCTION; LUNG INJURY; EXOSOMES; DELIVERY; REPAIR; MICROVESICLES; GROWTH;
D O I：
10.3390/cells9030707
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Extracellular vesicles (EVs), which are the main paracrine components of stem cells, mimic the regenerative capacity of these cells. Stem cell-derived EVs (SC-EVs) have been used for the treatment of various forms of tissue injury in preclinical trials through maintenance of their stemness, induction of regenerative phenotypes, apoptosis inhibition, and immune regulation. The efficiency of SC-EVs may be enhanced by selecting the appropriate EV-producing cells and cell phenotypes, optimizing cell culture conditions for the production of optimal EVs, and further engineering the EVs produced to transport therapeutic and targeting molecules.
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页数：28
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