Therapeutic Advances of Stem Cell-Derived Extracellular Vesicles in Regenerative Medicine

被引：67
作者：
Yin, Lei [1 ]
Liu, Xiaotian [1 ]
Shi, Yinghong [1 ]
Ocansey, Dickson Kofi Wiredu [1 ]
Hu, Yuyan [1 ]
Li, Xiaoxi [1 ]
Zhang, Chenxiao [1 ]
Xu, Wenrong [1 ]
Qian, Hui [1 ]
机构：
[1] Jiangsu Univ, Zhenjiang Key Lab High Technol Res Exosomes Fdn &, Sch Med, Jiangsu Key Lab Med Sci & Lab Med, 301 Xuefu Rd, Zhenjiang 212013, Jiangsu, Peoples R China
来源：
CELLS | 2020年 / 9卷 / 03期
基金：
中国国家自然科学基金;
关键词：
stem cell; extracellular vesicle; tissue damage; regenerative medicine; MESENCHYMAL STROMAL CELLS; FUNCTIONAL RECOVERY; ONCOLYTIC ADENOVIRUS; CARDIAC-FUNCTION; LUNG INJURY; EXOSOMES; DELIVERY; REPAIR; MICROVESICLES; GROWTH;
D O I：
10.3390/cells9030707
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Extracellular vesicles (EVs), which are the main paracrine components of stem cells, mimic the regenerative capacity of these cells. Stem cell-derived EVs (SC-EVs) have been used for the treatment of various forms of tissue injury in preclinical trials through maintenance of their stemness, induction of regenerative phenotypes, apoptosis inhibition, and immune regulation. The efficiency of SC-EVs may be enhanced by selecting the appropriate EV-producing cells and cell phenotypes, optimizing cell culture conditions for the production of optimal EVs, and further engineering the EVs produced to transport therapeutic and targeting molecules.
引用
收藏
页数：28
相关论文
共 114 条
[1]   Substantial Overview on Mesenchymal Stem Cell Biological and Physical Properties as an Opportunity in Translational Medicine [J].
Abdelrazik, Heba ;
Giordano, Emanuele ;
Brodano, Giovanni Barbanti ;
Griffoni, Cristiana ;
De Falco, Elena ;
Pelagalli, Alessandra .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (21)
[2]   Biodistribution of gadolinium- and near infrared-labeled human umbilical cord mesenchymal stromal cell-derived exosomes in tumor bearing mice [J].
Abello, Javier ;
Tuyen Duong Thanh Nguyen ;
Marasini, Ramesh ;
Aryal, Santosh ;
Weiss, Mark Louis .
THERANOSTICS, 2019, 9 (08) :2325-2345
[3]   Induced Pluripotent Stem Cell (iPSC)-Derived Extracellular Vesicles Are Safer and More Effective for Cardiac Repair Than iPSCs [J].
Adamiak, Marta ;
Cheng, Guangming ;
Bobis-Wozowicz, Sylwia ;
Zhao, Lin ;
Kedracka-Krok, Sylwia ;
Samanta, Anweshan ;
Karnas, Elzbieta ;
Xuan, Yu-Ting ;
Skupien-Rabian, Bozena ;
Chen, Xing ;
Jankowska, Urszula ;
Girgis, Magdy ;
Sekula, Malgorzata ;
Davani, Arash ;
Lasota, Slawomir ;
Vincent, Robert J. ;
Sarna, Michal ;
Newell, Kathy L. ;
Wang, Ou-Li ;
Dudley, Nathaniel ;
Madeja, Zbigniew ;
Dawn, Buddhadeb ;
Zuba-Surma, Ewa K. .
CIRCULATION RESEARCH, 2018, 122 (02) :296-309
[4]   Vascular endothelial growth factor mediates the therapeutic efficacy of mesenchymal stem cell-derived extracellular vesicles against neonatal hyperoxic lung injury [J].
Ahn, So Yoon ;
Park, Won Soon ;
Kim, Young Eun ;
Sung, Dong Kyung ;
Sung, Se In ;
Ahn, Jee Yin ;
Chang, Yun Sil .
EXPERIMENTAL AND MOLECULAR MEDICINE, 2018, 50 :1-12
[5]   Engineered Exosome-Mediated Near-Infrared-II Region V2C Quantum Dot Delivery for Nucleus-Target Low-Temperature Photothermal Therapy [J].
Cao, Yu ;
Wu, Tingting ;
Zhang, Kai ;
Meng, Xiangdan ;
Dai, Wenhao ;
Wang, Dongdong ;
Dong, Haifeng ;
Zhang, Xueji .
ACS NANO, 2019, 13 (02) :1499-1510
[6]   The CD47-SIRPα pathway in cancer immune evasion and potential therapeutic implications [J].
Chao, Mark P. ;
Weissman, Irving L. ;
Majeti, Ravindra .
CURRENT OPINION IN IMMUNOLOGY, 2012, 24 (02) :225-232
[7]   Early gestational mesenchymal stem cell secretome attenuates experimental bronchopulmonary dysplasia in part via exosome-associated factor TSG-6 [J].
Chaubey, Sushma ;
Thueson, Sam ;
Ponnalagu, Devasena ;
Alam, Mohammad Afaque ;
Gheorghe, Ciprian P. ;
Aghai, Zubair ;
Singh, Harpreet ;
Bhandari, Vineet .
STEM CELL RESEARCH & THERAPY, 2018, 9
[8]   Exosomal DMBT1 from human urine-derived stem cells facilitates diabetic wound repair by promoting angiogenesis [J].
Chen, Chun-Yuan ;
Rao, Shan-Shan ;
Ren, Lu ;
Hu, Xiong-Ke ;
Tan, Yi-Juan ;
Hu, Yin ;
Luo, Juan ;
Liu, Yi-Wei ;
Yin, Hao ;
Huang, Jie ;
Cao, Jia ;
Wang, Zhen-Xing ;
Liu, Zheng-Zhao ;
Liu, Hao-Ming ;
Tang, Si-Yuan ;
Xu, Ran ;
Xie, Hui .
THERANOSTICS, 2018, 8 (06) :1607-1623
[9]   Exosomes derived from human adipose tissue-derived mesenchymal stem cells alleviate atopic dermatitis [J].
Cho, Byong Seung ;
Kim, Jin Ock ;
Ha, Dae Hyun ;
Yi, Yong Weon .
STEM CELL RESEARCH & THERAPY, 2018, 9
[10]   Mesenchymal stem cells in preclinical cancer cytotherapy: a systematic review [J].
Christodoulou, Ioannis ;
Goulielmaki, Maria ;
Devetzi, Marina ;
Panagiotidis, Mihalis ;
Koliakos, Georgios ;
Zoumpourlis, Vassilis .
STEM CELL RESEARCH & THERAPY, 2018, 9
12345678910