Template-assembled synthetic G-quartets (TASQs)

被引：59
|
作者：
Nikan, Mehran [1 ]
Sherman, John C. [1 ]
机构：
[1] Univ British Columbia, Dept Chem, Vancouver, BC V6T 1Z1, Canada
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 26期
关键词：
cavitands; G-quartets; nucleosides; supramolecular chemistry; template synthesis;
D O I：
10.1002/anie.200704199
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An unusual quartet: Four guanine residues have been efficiently "clicked" onto a cavitand to create a lipophilic template-assembled synthetic G-quartet (TASQ) structure in CDCl3. The TASQ manifests unusual cation-free structural integrity and stability. This cation-free basket, as well as corresponding potential cation-bound quartets and cation-induced quadruplexes may find applications in health therapies. (Figure Presented) © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：4900 / 4902
页数：3
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