Clinical Pharmacogenetics Implementation Consortium Guideline (CPIC) for CYP2C9 and Nonsteroidal Anti-Inflammatory Drugs

被引：226

作者：

Theken, Katherine N. ^{[1
]}

Lee, Craig R. ^{[2
]}

Gong, Li ^{[3
,4
]}

Caudle, Kelly E. ^{[5
]}

Formea, Christine M. ^{[6
,7
,8
]}

Gaedigk, Andrea ^{[9
,10
]}

Klein, Teri E. ^{[3
,4
]}

Agundez, Jose A. G. ^{[11
]}

Grosser, Tilo ^{[1
]}

机构：

[1] Univ Penn, Perelman Sch Med, Inst Translat Med & Therapeut, Philadelphia, PA 19104 USA

[2] Univ N Carolina, Eshelman Sch Pharm, Div Pharmacotherapy & Expt Therapeut, Chapel Hill, NC 27515 USA

[3] Stanford Univ, Dept Biomed Data Sci, Stanford, CA 94305 USA

[4] Stanford Univ, Dept Med, Stanford, CA 94305 USA

[5] St Jude Childrens Res Hosp, Dept Pharmaceut Sci, 332 N Lauderdale St, Memphis, TN 38105 USA

[6] Mayo Clin, Dept Pharm, Rochester, MN USA

[7] Mayo Clin, Ctr Individualized Med, Rochester, MN USA

[8] Intermt Healthcare, Dept Pharm & Intermt Precis Genom, Salt Lake City, UT USA

[9] Childrens Mercy Kansas City, Div Clin Pharmacol Toxicol & Therapeut Innovat, Kansas City, MO USA

[10] Univ Missouri, Sch Med, Kansas City, MO 64108 USA

[11] ARADyAL Inst Salud Carlos III, Univ Inst Mol Pathol Biomarkers, UEx, Caceres, Spain

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2020年 / 108卷 / 02期

基金：

美国国家卫生研究院;

关键词：

PHARMACOKINETICS; CELECOXIB; GENOTYPE; POLYMORPHISMS; INHIBITION; IBUPROFEN; IMPACT; RISK; CYTOCHROME-P450; ACENOCOUMAROL;

D O I：

10.1002/cpt.1830

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used analgesics due to their lack of addictive potential. However, NSAIDs have the potential to cause serious gastrointestinal, renal, and cardiovascular adverse events. CYP2C9 polymorphisms influence metabolism and clearance of several drugs in this class, thereby affecting drug exposure and potentially safety. We summarize evidence from the published literature supporting these associations and provide therapeutic recommendations for NSAIDs based on CYP2C9 genotype (updates at ).

引用

页码：191 / 200

页数：10

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