PTH-related peptide (PTHrP) in hypercalcemia

被引：73
作者：
Mundy, Gregory R. [1 ]
Edwards, James R. [1 ]
机构：
[1] Vanderbilt Univ, Dept Med, Div Clin Pharmacol, Vanderbilt Ctr Bone Biol, Nashville, TN 37232 USA
来源：
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2008年 / 19卷 / 04期
关键词：
D O I：
10.1681/ASN.2007090981
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
It is now 20 years since the tumor-associated factor parathyroid hormone-related peptide was identified. Since then, there have been significant changes in the understanding of the hypercalcemic syndromes associated with malignancy and with the role of this peptide in normal physiology as well as this specialized pathologic setting. Parathyroid hormone-related peptide has become a useful diagnostic tool in the differential diagnosis of hypercalcemia, and approaches to inhibit its expression or its effects by malignant cells hold promise for treating the hypercalcemia and osteolysis associated with some cancers.
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页码：672 / 675
页数：4
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