Synthesis of New Thieno[2,3-b]pyridine Derivatives Based on Fused Thiophenes

被引：3
|
作者：
Paronikyan, E. G. [1 ]
Harutyunyan, A. S. [1 ]
Paronikyan, R. G. [1 ]
机构：
[1] Natl Acad Sci Armenia, Sci Technol Ctr Organ & Pharmaceut Chem, Yerevan 0014, Armenia
来源：
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 56卷 / 03期
关键词：
thiophene; thieno[2,3-c]pyranes; thieno[2,3-b]pyridines; pyrano[4 ',3 ':4,5]thieno[2,3-b]pyridines; anticonvulsant activity;
D O I：
10.1134/S1070428020030094
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Conditions for the Gewald synthesis of 2-amino-5,5-dimethyl-4,7-dihydro-5H-thieno[2,3-c]pyrans from 2,2-dimethyltetrahydropyran-4-ones have been optimized, and the yields have been improved. A procedure has been developed for the synthesis of new pyrano[4',3':4,5]thieno[2,3-b]pyridines by the Thorpe-Ziegler reaction of thieno[2,3-c]pyrans. Anticonvulsant activity of the synthesized compounds was studied.
引用
收藏
页码：422 / 428
页数：7
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