Thermoresponsive Chlorambucil Derivatives for Tumour Targeting

被引：28
作者：
Clavel, Catherine M. [1 ]
Zava, Olivier [1 ]
Schmitt, Frederic [2 ]
Kenzaoui, Blanka Halamoda [2 ]
Nazarov, Alexey A. [1 ]
Juillerat-Jeanneret, Lucienne [2 ]
Dyson, Paul J. [1 ]
机构：
[1] Ecole Polytech Fed Lausanne, Inst Sci & Ingn Chim, CH-1015 Lausanne, Switzerland
[2] CHU Vaudois, Univ Inst Pathol, CH-1011 Lausanne, Switzerland
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 31期
关键词：
antitumor agents; drug design; fluorine; hyperthermia; thermoactivity; THERMOSENSITIVE LIPOSOMES; FLUOROUS CATALYSIS; COMET ASSAY; DNA-DAMAGE; TEMPERATURE; HYPERTHERMIA; SOLVENTS; CELLS;
D O I：
10.1002/anie.201101133
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Putting the heat on: Drugs that are essentially inactive at 37°C and are active under mild hyperthermia can be synthesized by modification of chlorambucil with thermoresponsive groups (see picture; C gray, Cl green, F yellow, H white, N blue, O red). This modification should allow this cytotoxic agent to be used in a more targeted fashion, and consequently, with reduced side-effects. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：7124 / 7127
页数：4
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