Role of guanylate binding protein-1 in vascular defects associated with chronic inflammatory diseases

被引：27

作者：

Hammon, Matthias ^{[2
]}

Herrmann, Martin ^{[3
]}

Bleiziffer, Oliver ^{[2
]}

Pryymachuk, Galyna ^{[2
]}

Andreoli, Laura ^{[4
]}

Munoz, Luis E. ^{[3
]}

Amann, Kerstin U. ^{[5
]}

Mondini, Michele ^{[6
]}

Gariglio, Marisa ^{[6
]}

Airo, Paolo ^{[4
]}

Schellerer, Vera S.

Hatzopoulos, Antonis K. ^{[7
]}

Horch, Raymund E. ^{[2
]}

Kneser, Ulrich ^{[2
]}

Stuerzl, Michael ^{[1
]}

Naschberger, Elisabeth ^{[1
]}

机构：

[1] Univ Med Ctr Erlangen, Dept Surg, Div Mol & Expt Surg, D-91054 Erlangen, Germany

[2] Univ Med Ctr Erlangen, Dept Plast & Hand Surg, D-91054 Erlangen, Germany

[3] Univ Med Ctr Erlangen, Dept Internal Med 3, Inst Clin Immunol & Rheumatol, D-91054 Erlangen, Germany

[4] Univ Clin Brescia, Brescia, Italy

[5] Univ Med Ctr Erlangen, Inst Pathol, Div Nephropathol, D-91054 Erlangen, Germany

[6] Univ Piemonte Orientale, Dept Clin & Expt Med, Novara, Italy

[7] Vanderbilt Univ, Sch Med, Dept Med, Div Cardiovasc Med, Nashville, TN 37212 USA

来源：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2011年 / 15卷 / 07期

关键词：

rheumatic autoimmune disorders; guanylate binding protein-1; endothelial progenitor cells; inflammation; systemic lupus erythematosus; rheumatoid arthritis; systemic sclerosis; ENDOTHELIAL PROGENITOR CELLS; SYSTEMIC-LUPUS-ERYTHEMATOSUS; RHEUMATOID-ARTHRITIS; AUTOIMMUNE-DISEASES; PERIPHERAL-BLOOD; REVISED CRITERIA; ANGIOGENESIS; INTERFERON; GTPASE; CLASSIFICATION;

D O I：

10.1111/j.1582-4934.2010.01146.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Rheumatic autoimmune disorders are characterized by a sustained pro-inflammatory microenvironment associated with impaired function of endothelial progenitor cells (EPC) and concomitant vascular defects. Guanylate binding protein-1 (GBP-1) is a marker and intracellular regulator of the inhibition of proliferation, migration and invasion of endothelial cells induced by several pro-inflammatory cytokines. In addition, GBP-1 is actively secreted by endothelial cells. In this study, significantly increased levels of GBP-1 were detected in the sera of patients with chronic inflammatory disorders. Accordingly we investigated the function of GBP-1 in EPC. Interestingly, stable expression of GBP-1 in T17b EPC induced premature differentiation of these cells, as indicated by a robust up-regulation of both Flk-1 and von Willebrand factor expression. In addition, GBP-1 inhibited the proliferation and migration of EPC in vitro. We confirmed that GBP-1 inhibited vessel-directed migration of EPC at the tissue level using the rat arterio-venous loop model as a novel quantitative in vivo migration assay. Overall, our findings indicate that GBP-1 contributes to vascular dysfunction in chronic inflammatory diseases by inhibiting EPC angiogenic activity via the induction of premature EPC differentiation.

引用

页码：1582 / 1592

页数：11

共 46 条

[1] Effect of anti-TNFα treatment on circulating endothelial progenitor cells (EPCs) in rheumatoid arthritis [J].

Ablin, Jacob N. ;

Boguslavski, Viktoria ;

Aloush, Valerie ;

Elkayam, Ori ;

Paran, Daphna ;

Caspi, Dan ;

George, Jacob .

LIFE SCIENCES, 2006, 79 (25) :2364-2369

[2] Evaluation of blood vessel ingrowth in fibrin gel subject to type and concentration of growth factors [J].

Arkudas, A. ;

Tjiawi, J. ;

Saumweber, A. ;

Beier, J. P. ;

Polykandriotis, E. ;

Bleiziffer, O. ;

Horch, R. E. ;

Kneser, U. .

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2009, 13 (9A) :2864-2874

[3] Fibrin gel-immobilized VEGF and bFGF efficiently stimulate angiogenesis in the AV loop model [J].

Arkudas, Andreas ;

Tjiawi, Jimmy ;

Bleiziffer, Oliver ;

Grabinger, Lucia ;

Polykandriotis, Elias ;

Beier, Justus P. ;

Stuerzl, Michael ;

Horch, Raymund E. ;

Kneser, Ulrich .

MOLECULAR MEDICINE, 2007, 13 (9-10) :480-487

[4] THE AMERICAN-RHEUMATISM-ASSOCIATION 1987 REVISED CRITERIA FOR THE CLASSIFICATION OF RHEUMATOID-ARTHRITIS [J].

ARNETT, FC ;

EDWORTHY, SM ;

BLOCH, DA ;

MCSHANE, DJ ;

FRIES, JF ;

COOPER, NS ;

HEALEY, LA ;

KAPLAN, SR ;

LIANG, MH ;

LUTHRA, HS ;

MEDSGER, TA ;

MITCHELL, DM ;

NEUSTADT, DH ;

PINALS, RS ;

SCHALLER, JG ;

SHARP, JT ;

WILDER, RL ;

HUNDER, GG .

ARTHRITIS AND RHEUMATISM, 1988, 31 (03) :315-324

[5] Isolation of putative progenitor endothelial cells for angiogenesis [J].

Asahara, T ;

Murohara, T ;

Sullivan, A ;

Silver, M ;

vanderZee, R ;

Li, T ;

Witzenbichler, B ;

Schatteman, G ;

Isner, JM .

SCIENCE, 1997, 275 (5302) :964-967

[6] VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells [J].

Asahara, T ;

Takahashi, T ;

Masuda, H ;

Kalka, C ;

Chen, DH ;

Iwaguro, H ;

Inai, Y ;

Silver, M ;

Isner, JM .

EMBO JOURNAL, 1999, 18 (14) :3964-3972

[7] Endothelial progenitor cells and rheumatic disorders [J].

Avouac, Jerome ;

Uzan, Georges ;

Kahan, Andre ;

Boileau, Catherine ;

Allanore, Yannick .

JOINT BONE SPINE, 2008, 75 (02) :131-137

[8] Type I interferon in systemic lupus erythematosus and other autoimmune diseases [J].

Banchereau, Jacques ;

Pascual, Virginia .

IMMUNITY, 2006, 25 (03) :383-392

[9] UP-REGULATION OF ENDOTHELIAL-CELL ADHESION MOLECULES CHARACTERIZES DISEASE-ACTIVITY IN SYSTEMIC LUPUS-ERYTHEMATOSUS - THE SHWARTZMAN PHENOMENON REVISITED [J].

BELMONT, HM ;

BUYON, J ;

GIORNO, R ;

ABRAMSON, S .

ARTHRITIS AND RHEUMATISM, 1994, 37 (03) :376-383

[10] T17b murine embryonal endothelial progenitor cells can be induced towards both proliferation and differentiation in a fibrin matrix [J].

Bleiziffer, Oliver ;

Horch, Raymund E. ;

Hammon, Matthias ;

Arkudas, Andreas ;

Naschberger, Elisabeth ;

Rath, Subha ;

Pryymachuk, Galyna ;

Beier, Justus P. ;

Hatzopoulos, Antonis K. ;

Stuerzl, Michael ;

Kneser, Ulrich .

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2009, 13 (05) :926-935

← 1 2 3 4 5 →