An asymmetric ent-kauranoid dimer from Isodon rubescens var. lushanensis

被引：27

作者：

Han, QB

Lu, Y

Wu, L

He, ZD

Qiao, CF

Xu, HX

Zheng, QT

Sun, HD ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phyotchem & Plant Resources W China, Kunming 650204, Peoples R China

[2] Inst Chinese Med, Hong Kong Jockey Club, Chinese Med Lab, Shatin, Hong Kong, Peoples R China

[3] Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 32期

关键词：

Isodon rubescens var. lushanensis; ent-Kaurane dimer; lushanrubescensin J; tetraacetate;

D O I：

10.1016/j.tetlet.2005.06.004

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel asymmetric ent-kauranoid dimer, lushanrubescensin J (1), was isolated from Isodon rubescens var. lushanensis. Its structure was elucidated by the spectroscopic evidences. The stereochemistry was confirmed by the single crystal X-ray diffraction of its tetraacetate. Compound (1) exhibited potent inhibitory activity against K562 cells with IC50 = 0.93 mu g/mL. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：5373 / 5375

页数：3

共 5 条

[1] A novel asymmetric ent-Kaurane dimer from Isodon rubescens var. rubescens [J].

Han, QB ;

He, ZD ;

Qiao, CF ;

Xu, HX ;

Sun, HD .

HELVETICA CHIMICA ACTA, 2005, 88 (04) :817-821

[2] Novel ent-kaurane dimers from Isodon rubescens var. rubescens [J].

Han, QB ;

Lu, Y ;

Zhang, LL ;

Zheng, QT ;

Sun, HD .

TETRAHEDRON LETTERS, 2004, 45 (13) :2833-2837

[3]

Han QB, 2003, HETEROCYCLES, V60, P933

[4]

Han QB, 2003, CHEM PHARM BULL, V51, P790, DOI 10.1248/cpb.51.790

[5]

HILL RA, 2004, NAT PROD REP, V21, pH9

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