Local Tumor Recurrence and Escape from Suppression of Bone Resorption With Denosumab Treatment in Two Adolescents With Giant Cell Tumors of Bone

被引：7

作者：

Akel, Umar ^{[1
]}

Robinson, Marie-Eve ^{[1
,2
]}

Werier, Joel ^{[3
]}

Rampersaud, Raja ^{[4
]}

Rakhra, Kawan ^{[3
]}

Johnston, Donna ^{[5
]}

Konji, Victor N. ^{[1
]}

Ma, Jinhui ^{[6
]}

Page, Marika ^{[1
]}

Matzinger, Mary Ann ^{[7
]}

Ward, Leanne M. ^{[1
,2
,3
]}

机构：

[1] Eastern Ontario Res Inst, Pediat Bone Hlth Clin Res Program, Childrens Hosp, Ottawa, ON, Canada

[2] Childrens Hosp Eastern, Dept Pediat, Div Endocrinol, Ottawa, ON, Canada

[3] Ottawa Hosp, Dept Surg, Div Orthopaed Surg, Ottawa, ON, Canada

[4] Univ Hlth Network, Div Orthopaed, Dept Surg, Toronto, ON, Canada

[5] Childrens Hosp Eastern Ontario, Div Hematol Oncol, Dept Pediat, Ottawa, ON, Canada

[6] McMaster Univ, Dept Hlth Res Methods Evidence & Impact, Hamilton, ON, Canada

[7] Childrens Hosp Eastern Ontario, Dept Diagnost Imaging, Ottawa, ON, Canada

来源：

JBMR PLUS | 2019年 / 3卷 / 09期

关键词：

DENOSUMAB; GIANT CELL TUMOR; ADOLESCENTS; HYPOCALCEMIA; HYPERCALCEMIA; REBOUND;

D O I：

10.1002/jbm4.10196

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Giant cell tumors of bone (GCTB) may be difficult to resect because of size or location. We describe two adolescents who were treated with denosumab and followed for tumoral and biochemical responses. Denosumab was effective in achieving sufficient regression to allow surgical resection and in preserving peritumor cortical bone. Reactivation of bone resorption markers was noted while the patients were receiving monthly denosumab. One patient suffered a local tumor recurrence. Denosumab was safe in enabling surgical resection of GCTB. However, the effect was transient, with an escape of resorption markers and tumor recurrence. (C) 2019 The Authors. JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.

引用

页数：5

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