The Role of Sirolimus in the Prevention of Cutaneous Squamous Cell Carcinoma in Organ Transplant Recipients

被引：0

作者：

Leblanc, Keith G., Jr. ^{[1
]}

Hughes, Matthew P.

Sheehan, Daniel J. ^{[1
]}

机构：

[1] Med Coll Georgia, Dermatol Sect, Augusta, GA 30904 USA

来源：

DERMATOLOGIC SURGERY | 2011年 / 37卷 / 06期

关键词：

NONMELANOMA SKIN-CANCER; CALCINEURIN INHIBITORS; CLINICAL-COURSE; RISK-FACTORS; PROGRESSION; IMMUNOSUPPRESSION; CONVERSION; EPIDEMIOLOGY; KIDNEY; GROWTH;

D O I：

10.1111/j.1524-4725.2011.01973.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Skin cancers are common in organ transplant recipients (OTRs). In this review, we discuss the epidemiology of and risk factors for cutaneous neoplasms, particularly squamous cell carcinoma (SCC) in OTRs. The pathogenesis of SCC is reviewed, as well as the potential mechanisms for tumor progression and metastasis associated with two commonly used immunosuppressive medications: tacrolimus and cyclosporine. Finally, we discuss the mechanism of action and potential preventative use of sirolimus, a member of a newer class of immunosuppressants, the mammalian target of rapamycin inhibitors.

引用

页码：744 / 749

页数：6

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