Bactericidal Block Copolymer Micelles

被引：16

作者：

Vyhnalkova, Renata ^{[1
]}

Eisenberg, Adi ^{[2
]}

van de Ven, Theo ^{[1
]}

机构：

[1] McGill Univ, Pulp & Paper Res Ctr, Montreal, PQ H3A 2A7, Canada

[2] McGill Univ, Montreal, PQ H3A 2K6, Canada

来源：

MACROMOLECULAR BIOSCIENCE | 2011年 / 11卷 / 05期

基金：

加拿大自然科学与工程研究理事会;

关键词：

biological application of polymers; block copolymers; micelles; CYLINDRICAL MICELLES; MORPHOLOGIES; BEHAVIOR; SOLUBILIZATION; VESICLES; STAR;

D O I：

10.1002/mabi.201000428

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Block copolymer micelles with bactericidal properties were designed to deactivate pathogens such as E. coli bacteria. The micelles of PS-b-PAA and PS-b-P4VP block copolymers were loaded with biocides TCMTB or TCN up to 20 or 30 wt.-%, depending on the type of antibacterial agent. Bacteria were exposed to loaded micelles and bacterial deactivation was evaluated. The micelles loaded with TCN are bactericidal; bacteria are killed in less than two minutes of exposure. The most likely interpretation of the data is that the biocide is transferred to the bacteria by repeated micelle/bacteria contacts, and not via the solution.

引用

页码：639 / 651

页数：13

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