Synthesis of 1,2,3-triazole-linked pyrrolobenzodiazepine conjugates employing 'click' chemistry: DNA-binding affinity and anticancer activity

被引：147

作者：

Kamal, Ahmed ^{[1
]}

Shankaraiah, N. ^{[1
]}

Devaiah, V. ^{[1
]}

Reddy, K. Laxma ^{[1
]}

Juvekar, Aarti ^{[2
]}

Sen, Subrata ^{[2
]}

Kurian, Nisha ^{[2
]}

Zingde, Surekha ^{[2
]}

机构：

[1] Indian Inst Chem Technol, Div Organ Chem, Biotransformat Lab, Hyderabad 500007, Andhra Pradesh, India

[2] Adv Ctr Treatment Res & Educ Canc, Bombay, Maharashtra, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 04期

关键词：

D O I：

10.1016/j.bmcl.2007.12.063

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

1,2,3-Triazole based molecules are useful pharmacophores for several DNA-alkylating and cross-linking agents. A series of A/C8, C/C2 and A/C8-C/C2-linked 1,2,3-triazole-PBD conjugates have been synthesized by employing 'click' chemistry. These molecules have exhibited promising DNA-binding affinity and anticancer activity in selected human cancer cell lines. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：1468 / 1473

页数：6

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