Effect of aminoguanidine on lipid peroxidation and activities of antioxidant enzymes in the diabetic kidney

被引：0
|
作者：
Kedziora-Kornatowska, K [1 ]
Luciak, M [1 ]
机构：
[1] Mil Med Univ, Dept Internal Med, PL-90647 Lodz, Poland
来源：
BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL | 1998年 / 46卷 / 03期
关键词：
diabetes; lipid peroxidation; kidney; oxidative stress; catalase; superoxide dismutase;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The aim of this study was to examine lipid peroxidation and activities of key antioxidant enzymes in kidneys of rats with streptozotocin (STZ)-induced diabetes and the effect of aminoguanidine on diabetes-induced alterations. Three groups, 6 rats each, were studied: control animals, not treated diabetic rats and rats treated with aminoguanidine (AG; 1 g/liter of drinking water). After 6 and 12 weeks the animals were sacrificed and lipid peroxidation products and activities of antioxidant enzymes were determined in their kidney homogenates. Malondialdehyde (MDA) content was significantly elevated and activities of SOD and catalase decreased in the kidneys of STZ-diabetic rats. AG treatment attenuated the increase in MDA content and diminutions of activities of SOD and catalase in. the kidneys of diabetic rats. These results confirm oxidative stress in the kidney of rats with STZ diabetes and point to an antioxidant effect of AG in experimental diabetes.
引用
收藏
页码：577 / 583
页数：7
相关论文
共 50 条
  • [31] Antioxidant enzymes activity and lipid peroxidation in liver and kidney of rats exposed to cadmium and ethanol
    Jurczuk, M
    Brzóska, MM
    Moniuszko-Jakoniuk, J
    Galazyn-Sidorczuk, M
    Kulikowska-Karpinska, E
    FOOD AND CHEMICAL TOXICOLOGY, 2004, 42 (03) : 429 - 438
  • [32] Antioxidant status and lipid peroxidation in diabetic pregnancy
    Bates, JH
    Young, IS
    Galway, L
    Traub, AI
    Hadden, DR
    BRITISH JOURNAL OF NUTRITION, 1997, 78 (04) : 523 - 532
  • [33] Antioxidant enzyme activities and lipid peroxidation in preeclampsia
    Biri, A.
    Bozkurt, N.
    Gunaydin, G.
    Korucuoglu, U.
    Durak, I.
    Kavutcu, M.
    INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS, 2007, 96 (03) : 196 - 197
  • [34] Acute toxicity effect of paraoxon on kidney lipid peroxidation and antioxidant system
    Abbasnezhad, Maryam
    Jafari, Mahvash
    HagHooseni, Reza
    Haggholamali, Mansore
    Salehi, Maryam
    Salimian, Mohamad
    TOXICOLOGY LETTERS, 2009, 189 : S125 - S125
  • [35] The effect of bisphenol AF on lipid peroxidation and antioxidant enzymes activity in human erythrocytes
    Macczak, A.
    Bukowska, B.
    Michalowicz, J.
    TOXICOLOGY LETTERS, 2016, 258 : S250 - S250
  • [36] The effect of different drought stress on antioxidant enzymes and lipid peroxidation on Zoysia japonica
    Chen, Zhonglin
    Xu, Sunan
    Li, Yue
    Xie, Shi
    Fan, Lixia
    Zhang, Lihong
    ADVANCES IN ENVIRONMENTAL SCIENCE AND ENGINEERING, PTS 1-6, 2012, 518-523 : 5489 - 5492
  • [37] In vitro effect of organophosphate pesticides, Malathion and chlorpyriphos, on lipid peroxidation and antioxidant enzymes
    Font, Guillermina
    Juan-Garcia, Ana
    Fernandez, Monica
    Jose Ruiz, Maria
    TOXICOLOGY LETTERS, 2008, 180 : S103 - S104
  • [38] Effects of melatonin on lipid peroxidation and antioxidant enzymes in streptozotocin-induced diabetic rat testis
    Armagan, Abdullah
    Uz, Efkan
    Yilmaz, H. Ramazan
    Soyupek, Sedat
    Oksay, Taylan
    Ozcelik, Nurten
    ASIAN JOURNAL OF ANDROLOGY, 2006, 8 (05) : 595 - 600
  • [39] Effects of melatonin on lipid peroxidation and antioxidant enzymes in streptozotocin-induced diabetic rat testis
    Abdullah Armagan
    EfkanUz
    H.RamazanYilmaz
    SedatSoyupek
    TaylanOksay
    Nurten Ozcelik
    AsianJournalofAndrology, 2006, (05) : 595 - 600
  • [40] Effects of caffeic acid phenethyl ester on lipid peroxidation and antioxidant enzymes in diabetic rat heart
    Okutan, H
    Ozcelik, N
    Yilmaz, HR
    Uz, E
    CLINICAL BIOCHEMISTRY, 2005, 38 (02) : 191 - 196
12345