Light-Driven ATP Transmembrane Transport Controlled by DNA Nanomachines

被引：97

作者：

Li, Pei ^{[1
,2
]}

Xie, Ganhua ^{[1
]}

Liu, Pei ^{[1
,3
]}

Kong, Xiang-Yu ^{[1
]}

Song, Yanlin ^{[4
]}

Wen, Liping ^{[1
,3
]}

Jiang, Lei ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Sci, CAS Key Lab Bioinspired Mat & Interfacial Sci, Tech Inst Phys & Chem, Beijing 100190, Peoples R China

[2] Beihang Univ, Sch Chem, Key Lab Bioinspired Smart Interfacial Sci & Techn, Minist Educ, Beijing 100191, Peoples R China

[3] Univ Chinese Acad Sci, Sch Future Technol, Beijing 100049, Peoples R China

[4] Chinese Acad Sci, Inst Chem, Key Lab Green Printing, Beijing 100190, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2018年 / 140卷 / 47期

基金：

国家重点研发计划;

关键词：

ION-TRANSPORT; APTAMER; MEMBRANES; SWITCHES; CHANNELS; RELEASE; DUPLEX; CELLS;

D O I：

10.1021/jacs.8b10527

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In nature, biological machines can perform sophisticated and subtle functions to maintain the metabolism of organisms. Inspired from these gorgeous works of nature, scientists have developed various artificial molecular motors and machines. However, selective transport of biomolecules across membrane has remained a great challenge. Here, we establish an ATP transport system by assembling photocontrolled DNA nano machines into the artificial nanochannels. With alternant light irradiation, these ATP transport lines can selectively shepherd cargoes across the polymer membrane. These findings point to new opportunities for manipulating and improving the mass transportation and separation with light-controlled biomolecular motors, and can be used for other molecules and ions transmembrane transport powered by light.

引用

页码：16048 / 16052

页数：5

共 47 条

[1] DNA duplex-quadruplex exchange as the basis for a nanomolecular machine [J].

Alberti, P ;

Mergny, JL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (04) :1569-1573

[2]

[Anonymous], ANN NY ACAD SCI

[3]

Asanuma H, 1999, ANGEW CHEM INT EDIT, V38, P2393, DOI 10.1002/(SICI)1521-3773(19990816)38:16<2393::AID-ANIE2393>3.0.CO

[4]

2-7

[5] Synthesis of azobenzene-tethered DNA for reversible photo-regulation of DNA functions: hybridization and transcription [J].

Asanuma, Hiroyuki ;

Liang, Xingguo ;

Nishioka, Hidenori ;

Matsunaga, Daijiro ;

Liu, Mingzhe ;

Komiyama, Makoto .

NATURE PROTOCOLS, 2007, 2 (01) :203-212

[6] A molecular elevator [J].

Badjic, JD ;

Balzani, V ;

Credi, A ;

Silvi, S ;

Stoddart, JF .

SCIENCE, 2004, 303 (5665) :1845-1849

[7] Pannexin membrane channels are mechanosensitive conduits for ATP [J].

Bao, L ;

Locovei, S ;

Dahl, G .

FEBS LETTERS, 2004, 572 (1-3) :65-68

[8] Pannexin 1 in the Regulation of Vascular Tone [J].

Billaud, Marie ;

Sandilos, Joanna K. ;

Isakson, Brant E. .

TRENDS IN CARDIOVASCULAR MEDICINE, 2012, 22 (03) :68-72

[9]

Burnstock G, 1995, Pharm Acta Helv, V69, P231, DOI 10.1016/0031-6865(94)00043-U

[10] Purinergic signalling and disorders of the central nervous system [J].

Burnstock, Geoffrey .

NATURE REVIEWS DRUG DISCOVERY, 2008, 7 (07) :575-590

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