Strategy for Detecting Carbon Monoxide: Cu2+-Assisted Fluorescent Probe and Its Applications in Biological Imaging

被引：29

作者：

Bai, Cuibing ^{[1
,2
]}

Zhang, Jie ^{[1
]}

Qin, Yuxin ^{[1
]}

Meng, Qian ^{[1
]}

Yao, Junxiong ^{[1
]}

Huang, Huanan ^{[4
]}

Wei, Biao ^{[1
]}

Li, Ruiqian ^{[1
]}

Zhang, Lin ^{[1
]}

Miao, Hui ^{[1
]}

Qu, Changqing ^{[3
]}

Qiao, Rui ^{[1
,2
]}

机构：

[1] Fuyang Normal Univ, Engn Res Ctr Biomass Convers & Pollut Prevent Anh, Sch Chem & Mat Engn, Fuyang 236037, Peoples R China

[2] Chinese Acad Sci, Tech Inst Phys & Chem, Key Lab Photochem Convers & Optoelect Mat, Beijing 100190, Peoples R China

[3] Res Ctr Antiaging Chinese Herbal Med Anhui Prov, Fuyang 236037, Peoples R China

[4] Jiujiang Univ, Coll Chem & Chem Engn, Jiangxi Prov Engn Res Ctr Ecol Chem Ind, Xinghuo Organosilicon Ind Res Ctr, Jiujiang 332005, Peoples R China

来源：

ANALYTICAL CHEMISTRY | 2022年 / 94卷 / 32期

基金：

中国国家自然科学基金;

关键词：

LIVING CELLS; REDUCTION; CU; METALS; CU(II); OXIDE;

D O I：

10.1021/acs.analchem.2c01948

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Herein, a novel strategy was proposed for identifying carbon monoxide (CO), which plays a crucial part in living systems. For the first time, we have managed to design, synthesize, and characterize successfully this new Cu2+-assisted fluorescent probe (DPHP) in detecting CO. Compared with the commonly adopted Pd-0-mediated Tsuji-Trost reaction recognition method, such a new strategy did not engage costly palladium (II) salt and generated no leaving group, indicating a satisfactory anti-interference ability. The recognition mechanism was confirmed by IR, H-1 NMR titration, HR-MS, cyclic voltammetry, X-ray photoelectron spectroscopy, electron paramagnetic resonance, and optical properties. Surprisingly, it was found that the new method achieved high selectivity and rapid identification of CO with a lower limit of detection (1.7 x 10(-8) M). More intriguingly, it could recognize endogenous and exogenous CO in HeLa cells. The cytotoxicity of this new method was so low that it allowed the detection of CO in mice and zebrafish. Basically, our results trigger a novel viewpoint of rationally designing and synthesizing advanced materials for CO detection with unique features, impelling new research in detection chemistry.

引用

页码：11298 / 11306

页数：9

共 51 条

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