Induction of sister chromatid exchanges by pyrimethamine in human lymphocyte cultures

被引：0
作者：
Egeli, Ü [1 ]
机构：
[1] Univ Uludag, Fac Med, Dept Med Biol, Bursa, Turkey
来源：
TERATOGENESIS CARCINOGENESIS AND MUTAGENESIS | 1998年 / 18卷 / 04期
关键词：
pyrimethamine; sister chromatid exchanges; human lymphocyte culture; genotoxicity; toxoplasmosis;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
This study examined the effect of pyrimethamine (PYR) on sister chromatid exchanges (SCEs) in human lymphocytes. PYR is a folic acid antagonist used for the treatment of malaria and toxoplasmosis. PYR was added to peripheral blood lymphocyte cultures at three different doses: 0.05, 0.1, and 0.2 mg/ml. The results of the cytogenetic and statistical evaluations showed that the frequency of SCEs increased significantly in a dose-dependent manner. Thus, it is shown that PYR has a genotoxic effect on human chromosomes. Teratogenesis Carcinog. Mutagen. 18:163-169, 1998. (C) 1998 Wiley-Liss, Inc.
引用
收藏
页码：163 / 169
页数：7
相关论文
共 39 条
[1]   MOUSE MICRONUCLEUS TESTS WITH KNOWN AND SUSPECT SPINDLE POISONS - RESULTS FROM 2 LABORATORIES [J].
ADLER, ID ;
KLIESCH, U ;
VANHUMMELEN, P ;
KIRSCHVOLDERS, M .
MUTAGENESIS, 1991, 6 (01) :47-53
[2]   CHROMOSOMAL-ABERRATIONS AND SISTER-CHROMATID EXCHANGES IN WORKERS EXPOSED TO STYRENE [J].
CAMURRI, L ;
CODELUPPI, S ;
PEDRONI, C ;
SCARDUELLI, L .
MUTATION RESEARCH, 1983, 119 (3-4) :361-369
[3]   SISTER CHROMATID EXCHANGE AS AN INDICATOR OF MUTAGENESIS [J].
CARRANO, AV ;
THOMPSON, LH ;
LINDL, PA ;
MINKLER, JL .
NATURE, 1978, 271 (5645) :551-553
[4]   ANEUPLOIDY IN MAMMALIAN SOMATIC-CELLS INVIVO [J].
CIMINO, MC ;
TICE, RR ;
LIANG, JC .
MUTATION RESEARCH, 1986, 167 (1-2) :107-122
[5]   FRAGILE SITES AND STRUCTURAL REARRANGEMENTS IN CANCER [J].
DEBRAEKELEER, M ;
SMITH, B ;
LIN, CC .
HUMAN GENETICS, 1985, 69 (02) :112-116
[6]  
DIPELMA J, 1971, DRILLS PHARM MED, P1770
[7]  
DYKE VK, 1982, ANTIMALARIAL DRUGS
[8]  
Egeli U, 1997, TERATOGEN CARCIN MUT, V17, P59
[9]   THE CLASTOGENIC EFFECT OF PYRIMETHAMINE (DARAPRIM) ON HUMAN-CHROMOSOMES IN LYMPHOCYTE-CULTURES [J].
EGELI, U ;
ERDOGAN, G .
CELL BIOLOGY AND TOXICOLOGY, 1991, 7 (04) :347-356
[10]  
EGELI U, 1997, CANC GENET CYTOGENET, V20, P1
1234