Antibiotic prophylaxis with quinolones in transurethral surgery.

Much controversy exists as to the benefit of antimicrobial prophylaxis in transurethral surgery. Any urinary tract infection should be treated before proceeding with a transurethral operation. There is growing evidence that antimicrobial. prophylaxis is also beneficial in the case of preoperatively sterile urine, A single dose or short-term prophylaxis appears to be sufficient. As newer fluoroquinolones reach very high tissue concentrations, possess a suitable antimicrobial spectrum to cover most uropathogens and may also be administered orally, these new drugs represent an attractive choice for prophylaxis in transurethral surgery.