Spatial mapping of cancer tissues by OMICS technologies

被引：15

作者：

Ahmed, Rashid ^{[1
,2
,3
]}

Augustine, Robin ^{[2
]}

Valera, Enrique ^{[3
,4
]}

Ganguli, Anurup ^{[3
,4
]}

Mesaeli, Nasrin ^{[5
]}

Ahmad, Irfan S. ^{[3
]}

Bashir, Rashid ^{[3
,4
,6
]}

Hasan, Anwarul ^{[1
,2
]}

机构：

[1] Qatar Univ, Coll Engn, Dept Mech & Ind Engn, Doha 2713, Qatar

[2] Qatar Univ, Biomed Res Ctr BRC, Doha 2713, Qatar

[3] Univ Illinois, Nick Holonyak Jr Micro & Nanotechnol Lab, Champaign, IL 61801 USA

[4] Univ Illinois, Dept Bioengn, Champaign, IL 61801 USA

[5] Weill Cornell Med Qatar, Dept Biochem, Qatar Fdn, Doha, Qatar

[6] Univ Illinois, Carle Illinois Coll Med, Champaign, IL 61801 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2022年 / 1877卷 / 01期

关键词：

Spatial profiling; OMICS technologies; Tumor tissues; Microarray technologies; Mass spectrometry; Single cell RNA sequencing; Digital pathology; IONIZATION MASS-SPECTROMETRY; GENOME-WIDE EXPRESSION; SINGLE CELLS; BIOLOGICAL TISSUE; GENE-EXPRESSION; TUMOR-TISSUES; IR-MALDESI; RNA; RESOLUTION; PROTEIN;

D O I：

10.1016/j.bbcan.2021.188663

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Spatial mapping of heterogeneity in gene expression in cancer tissues can improve our understanding of cancers and help in the rapid detection of cancers with high accuracy and reliability. Significant advancements have been made in recent years in OMICS technologies, which possess the strong potential to be applied in the spatial mapping of biopsy tissue samples and their molecular profiling to a single-cell level. The clinical application of OMICS technologies in spatial profiling of cancer tissues is also advancing. The current review presents recent advancements and prospects of applying OMICS technologies to the spatial mapping of various analytes in cancer tissues. We benchmark the current state of the art in the field to advance existing OMICS technologies for high throughput spatial profiling. The factors taken into consideration include spatial resolution, types of bio-molecules, number of different biomolecules that can be detected from the same assay, labeled versus label-free approaches, and approximate time required for each assay. Further advancements are still needed for the widespread application of OMICs technologies in performing fast and high throughput spatial mapping of cancer tissues as well as their effective use in research and clinical applications.

引用

页数：16

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