Incidence and Types of Human Papillomavirus Infections in Adolescent Girls and Young Women Immunized With the Human Papillomavirus Vaccine

被引:20
作者
Schlecht, Nicolas F. [1 ,2 ]
Diaz, Angela [3 ]
Nucci-Sack, Anne [3 ]
Shyhalla, Kathleen [1 ]
Shankar, Viswanathan [2 ]
Guillot, Mary [3 ]
Hollman, Dominic [3 ]
Strickler, Howard D.
Burk, Robert D. [2 ,4 ,5 ,6 ]
机构
[1] Roswell Pk Comprehens Canc Ctr, Dept Canc Prevent & Control, Elm & Carlton St, Buffalo, NY 14263 USA
[2] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA
[3] Icahn Sch Med Mt Sinai, Mt Sinai Adolescent Hlth Ctr, Dept Pediat, New York, NY USA
[4] Albert Einstein Coll Med, Dept Pediat Genet, Bronx, NY 10467 USA
[5] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10467 USA
[6] Albert Einstein Coll Med, Dept Obstet Gynecol & Womens Hlth, Bronx, NY 10467 USA
关键词
NUTRITION EXAMINATION SURVEY; AGED; 13-17; YEARS; UNITED-STATES; GENITAL WARTS; HPV VACCINE; NATIONAL-HEALTH; CERVICAL-CANCER; PREVALENCE; FEMALES; COVERAGE;
D O I
10.1001/jamanetworkopen.2021.21893
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Question Has the introduction of the vaccine for human papillomavirus (HPV) been associated with changes in infection rates among sexually active adolescent girls and young adult women? Findings This cohort study assessed HPV infection rates of vaccinated adolescent and young adult women at a large adolescent-specific health center in New York City. Age-adjusted cervical HPV detection of vaccine-related types were lower year over year, while the prevalence of nonvaccine high-risk HPV types remained flat or higher. Meaning These results indicate the real-world effectiveness of the HPV vaccines in female youth in New York City; nevertheless, rates of some nonvaccine high-risk HPV types were higher. IMPORTANCE Rates of human papillomavirus (HPV) infection have decreased since the introduction of HPV vaccines in populations with high vaccine uptake. Data are limited for adolescent and young adult populations in US metropolitan centers. OBJECTIVE To determine HPV infection rates in adolescent girls and young women aged 13 to 21 years in New York City following HPV vaccination. DESIGN, SETTING, AND PARTICIPANTS This cohort study of type-specific cervical HPV detection was conducted at a large adolescent-specific integrated health center in New York City between October 2007 and September 2019. Participants included an open cohort of adolescent girls and young adult women who received the HPV vaccine (Gardasil; Merck & Co) over a 12-year period following HPV vaccination introduction. Data analysis was concluded September 2019. EXPOSURES Calendar date and time since receipt of first vaccine dose. MAIN OUTCOMES AND MEASURES Temporal associations in age-adjusted postvaccine HPV rates. RESULTS A total of 1453 participants, with a mean (SD) age at baseline of 18.2 (1.4) years, were included in the cohort (African American with no Hispanic ethnicity, 515 [35.4%] participants; African American with Hispanic ethnicity, 218 [15.0%] participants; Hispanic with no reported race, 637 [43.8%] participants). Approximately half (694 [47.8%] participants) were vaccinated prior to coitarche. Age-adjusted detection rates for quadrivalent vaccine types (HPV-6, HPV-11, HPV-16, and HPV-18) and related types (HPV-31, and HPV-45) decreased year over year, with the largest effect sizes observed among individuals who had been vaccinated before coitarche (adjusted odds ratio [aOR], 0.81; 95% CI, 0.67-0.98). By contrast, detection was higher year over year for nonvaccine high-risk cervical HPV types (aOR, 1.08; 95% CI, 1.04-1.13) and anal HPV types (aOR, 1.11; 95% CI, 1.05-1.17). The largest effect sizes were observed with nonvaccine types HPV-56 and HPV-68. CONCLUSIONS AND RELEVANCE Whereas lower detection rates of vaccine-related HPV types were observed since introduction of vaccines in female youth in New York City, rates of some nonvaccine high-risk HPV types were higher. Continued monitoring of high-risk HPV prevalence is warranted. This cohort study of a single health center in New York City examines changes in human papillomavirus (HPV) infection rates among adolescent girls and young women following the introduction of a quadrivalent vaccine.
引用
收藏
页数:13
相关论文
共 56 条
[1]  
Abma Joyce C, 2017, Natl Health Stat Report, P1
[2]   Changes in Cervical Human Papillomavirus (HPV) Prevalence at a Youth Clinic in Stockholm, Sweden, a Decade After the Introduction of the HPV Vaccine [J].
Ahrlund-Richter, Andreas ;
Cheng, Liqin ;
Hu, Yue O. O. ;
Svensson, Mikaela ;
Pennhag, Alexandra A. L. ;
Ursu, Ramona G. ;
Haeggblom, Linnea ;
Grun, Nathalie ;
Ramqvist, Torbjorn ;
Engstrand, Lars ;
Dalianis, Tina ;
Du, Juan .
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2019, 9
[3]   Human papillomavirus DNA prevalence and type distribution in anal carcinomas worldwide [J].
Alemany, Laia ;
Saunier, Maelle ;
Alvarado-Cabrero, Isabel ;
Quiros, Beatriz ;
Salmeron, Jorge ;
Shin, Hai-Rim ;
Pirog, Edyta C. ;
Guimera, Nuria ;
Hernandez-Suarez, Gustavo ;
Felix, Ana ;
Clavero, Omar ;
Lloveras, Belen ;
Kasamatsu, Elena ;
Goodman, Marc T. ;
Hernandez, Brenda Y. ;
Laco, Jan ;
Tinoco, Leopoldo ;
Geraets, Daan T. ;
Lynch, Charles F. ;
Mandys, Vaclav ;
Poljak, Mario ;
Jach, Robert ;
Verge, Josep ;
Clavel, Christine ;
Ndiaye, Cathy ;
Klaustermeier, JoEllen ;
Cubilla, Antonio ;
Castellsague, Xavier ;
Bravo, Ignacio G. ;
Pawlita, Michael ;
Quint, William G. ;
Munoz, Nubia ;
Bosch, Francesc X. ;
de Sanjose, Silvia .
INTERNATIONAL JOURNAL OF CANCER, 2015, 136 (01) :98-107
[4]   Significant Decrease in the Incidence of Genital Warts in Young Danish Women After Implementation of a National Human Papillomavirus Vaccination Program [J].
Baandrup, Louise ;
Blomberg, Maria ;
Dehlendorff, Christian ;
Sand, Carsten ;
Andersen, Klaus K. ;
Kjaer, Susanne K. .
SEXUALLY TRANSMITTED DISEASES, 2013, 40 (02) :130-135
[5]   A review of human carcinogens-Part B: biological agents [J].
Bouvard, Veronique ;
Baan, Robert ;
Straif, Kurt ;
Grosse, Yann ;
Secretan, Beatrice ;
El Ghissassi, Fatiha ;
Benbrahim-Tallaa, Lamia ;
Guha, Neela ;
Freeman, Crystal ;
Galichet, Laurent ;
Cogliano, Vincent .
LANCET ONCOLOGY, 2009, 10 (04) :321-322
[6]   HPV vaccination has not increased sexual activity or accelerated sexual debut in a college-aged cohort of men and women [J].
Brouwer, Andrew F. ;
Delinger, Rachel L. ;
Eisenberg, Marisa C. ;
Campredon, Lora P. ;
Walline, Heather M. ;
Carey, Thomas E. ;
Meza, Rafael .
BMC PUBLIC HEALTH, 2019, 19 (1)
[7]   Decline in genital warts diagnoses among young women and young men since the introduction of the bivalent HPV (16/18) vaccination programme in England: an ecological analysis [J].
Canvin, M. ;
Sinka, K. ;
Hughes, G. ;
Mesher, D. .
SEXUALLY TRANSMITTED INFECTIONS, 2017, 93 (02) :125-128
[8]  
Castle PE, 2002, JNCI-J NATL CANCER I, V94, P1406, DOI 10.1093/jnci/94.18.1406
[9]   Evidence for cross-protection but not type-replacement over the 11 years after human papillomavirus vaccine introduction [J].
Covert, Courtney ;
Ding, Lili ;
Brown, Darron ;
Franco, Eduardo L. ;
Bernstein, David I. ;
Kahn, Jessica A. .
HUMAN VACCINES & IMMUNOTHERAPEUTICS, 2019, 15 (7-8) :1962-1969
[10]   Human papillomavirus genotype attribution in invasive cervical cancer: a retrospective cross-sectional worldwide study [J].
de Sanjose, Silvia ;
Quint, Wim G. V. ;
Alemany, Laia ;
Geraets, Daan T. ;
Ellen Klaustermeier, Jo ;
Lloveras, Belen ;
Tous, Sara ;
Felix, Ana ;
Eduardo Bravo, Luis ;
Shin, Hai-Rim ;
Vallejos, Carlos S. ;
Alonso de Ruiz, Patricia ;
Lima, Marcus Aurelho ;
Guimera, Nuria ;
Clavero, Omar ;
Alejo, Maria ;
Llombart-Bosch, Antonio ;
Cheng-Yang, Chou ;
Alejandro Tatti, Silvio ;
Kasamatsu, Elena ;
Iljazovic, Ermina ;
Odida, Michael ;
Prado, Rodrigo ;
Seoud, Muhieddine ;
Grce, Magdalena ;
Usubutun, Alp ;
Jain, Asha ;
Hernandez Suarez, Gustavo Adolfo ;
Estuardo Lombardi, Luis ;
Banjo, Aekunbiola ;
Menendez, Clara ;
Javier Domingo, Efren ;
Velasco, Julio ;
Nessa, Ashrafun ;
Chichareon, Saibua C. Bunnag ;
Qiao, You Lin ;
Lerma, Enrique ;
Garland, Suzanne M. ;
Sasagawa, Toshiyuki ;
Ferrera, Annabelle ;
Hammouda, Doudja ;
Mariani, Luciano ;
Pelayo, Adela ;
Steiner, Ivo ;
Oliva, Esther ;
Meijer, Chris J. L. M. ;
Al-Jassar, Waleed Fahad ;
Cruz, Eugenia ;
Wright, Thomas C. ;
Puras, Ana .
LANCET ONCOLOGY, 2010, 11 (11) :1048-1056